ArticleFrontiers in psychiatry2021
Poor Separation of Clinical Symptom Profiles by DSM-5 Disorder Criteria.
Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Multiscale Heterogeneity of White Matter Morphometry in Psychiatric Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- The impact of treatment processes on depression and anxiety outcomes in behavioral health treatment: a retrospective analysis.BMC psychology · 2026Article
- Maladaptive Personality Traits in Primary Care: Validation of the German Modified Brief Personality Inventory for DSM-5 (PID5BF + M).Assessment · 2026Article
- Exploring the lived experience of alcohol use disorder patients in accessing hospitalized treatment care in Rwanda.Discover mental health · 2026Article
- Individualized Subcortical Functional Brain Organization Is Related to Diagnosis, Symptoms, and Behavior in Major Depressive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Using network science to examine temporal relationships between 24-hour movement behaviors and depression during the transition to college: protocol for a prospective cohort study.Journal of activity, sedentary and sleep behaviors · 2026Article
- Using Network Science to Examine Temporal Relationships between 24-Hour Movement Behaviors and Depression During the Transition to College: Protocol for a Prospective Cohort Study.Research square · 2026Article
- Mental disorders & self-injurious thoughts and behaviors predict high risk of role impairment among university students - results from the world mental health international college student initiative.Journal of affective disorders · 2026Article
- Machine-actionable criteria chart the symptom space of mental disorders.NPJ digital medicine · 2026Article
- Validating an adaptive digital assessment of youth mental health needs: a cross-sectional study.NPJ digital medicine · 2026Article
- Article
- Identifying neuroimaging biomarkers for anxiety in emerging adults using machine learning and functional near-infrared spectroscopy during resting-state.Frontiers in psychiatry · 2026Article
- Transdiagnostic Network Mapping of Psychopathology in Daily Life: Rationale and Research Protocol.Clinical psychology in Europe · 2025Article
- Integrative gene and isoform co-expression networks reveal regulatory rewiring in stress-related psychiatric disorders.iScience · 2025Article
- Individualized functional brain mapping machine learning prediction of symptom-change resulting from selective kappa-opioid antagonism in an anhedonic sample from a Fast-Fail trial.Journal of mood and anxiety disorders · 2025Article
- A dimensional approach to psychosis: identifying cognition, depression, and thought disorder factors in a clinical sample.Schizophrenia (Heidelberg, Germany) · 2025Article
- Wearable fNIRS platform for dense sampling and precision functional neuroimaging.NPJ digital medicine · 2025Article
- Reconstructing Psychopathology: A Data-Driven Reorganization of the Symptoms in the Diagnostic and Statistical Manual of Mental Disorders.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Independent and Joint Associations of Physical Activity and Sleep on Mental Health Among a Global Sample of 200,743 Adults.International journal of behavioral medicine · 2025Article
- Contrasting genetic predisposition and diagnosis in psychiatric disorders: A multi-omic single-nucleus analysis of the human OFC.Science advances · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assessment of mental illness typically relies on a disorder classification system that is considered to be at odds with the vast disorder comorbidity and symptom heterogeneity that exists within and across patients. Patients with the same disorder diagnosis exhibit diverse symptom profiles and comorbidities creating numerous clinical and research challenges. Here we provide a quantitative analysis of the symptom heterogeneity and disorder comorbidity across a sample of 107,349 adult individuals (aged 18-85 years) from 8 English-speaking countries. Data were acquired using the Mental Health Quotient, an anonymous, online, self-report tool that comprehensively evaluates symptom profiles across 10 common mental health disorders. Dissimilarity of symptom profiles within and between disorders was then computed. We found a continuum of symptom prevalence rather than a clear separation of normal and disordered. While 58.7% of those with 5 or more clinically significant symptoms did not map to the diagnostic criteria of any of the 10 DSM-5 disorders studied, those with symptom profiles that mapped to at least one disorder had, on average, 20 clinically significant symptoms. Within this group, the heterogeneity of symptom profiles was almost as high within a disorder label as between 2 disorder labels and not separable from randomly selected groups of individuals with at least one of any of the 10 disorders. Overall, these results quantify the scale of misalignment between clinical symptom profiles and DSM-5 disorder labels and demonstrate that DSM-5 disorder criteria do not separate individuals from random when the complete mental health symptom profile of an individual is considered. Greater emphasis on empirical, disorder agnostic approaches to symptom profiling would help overcome existing challenges with heterogeneity and comorbidity, aiding clinical and research outcomes.
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