ReviewFrontiers in pharmacology2021
Mechanisms of Peripheral and Central Pain Sensitization: Focus on Ocular Pain.
Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 41 citations in OpenAlex.
- Activating Transcription Factor 3 in Pain: A Molecular Regulator and Emerging Biomarker.Genes · 2026Review
- Piezo1 Activation by Shear Stress Induces Corneal Epithelial Homeostasis Disruption.Investigative ophthalmology & visual science · 2026Article
- Current and Developing Therapeutics for Dry Eye Disease: Targeting Ion Channels.Current issues in molecular biology · 2026Review
- Emerging Technologies in Corneal Nerve Evaluation for Dry Eye and Ocular Surface Disease: A Review.Journal of clinical medicine · 2026Review
- Integrated management of dry eye-depression comorbidity: mechanistic insights and temporal therapeutic strategies.Frontiers in medicine · 2026Article
- Inflammatory Cytokine-Mediated Interactions Between Pain and Insomnia: Mechanisms and Therapeutic Implications.Journal of pain research · 2026Review
- Challenges using the Feline Grimace Scale in brachycephalic cats with ocular pain.Journal of feline medicine and surgery · 2026Article
- Mechanism of periocular acupuncture in alleviating dry eye neuropathic pain via regulation of the "periocular acupoint-trigeminal ganglion-ventral posteromedial thalamic nucleus" pathway.Frontiers in medicine · 2026Article
- Electrotherapy in the management of neuropathic corneal pain: narrative review.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Dry Eye Disease and Psychiatric Disorders: Neuroimmune Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2025Review
- Fibromyalgia in the Era of Brain PET/CT Imaging.Journal of clinical medicine · 2025Review
- Immunohistochemical Expression of Haptoglobin in Skin Lesions of Hidradenitis Suppurativa.Life (Basel, Switzerland) · 2025Article
- Characterization of Individuals with High-Frequency Artificial Tear Supplement Use.Journal of clinical medicine · 2025Article
- Neck pain associated with headache attributed to rhinosinusitis: an observational study.The Journal of manual & manipulative therapy · 2025Observational
- Delayed-Onset Muscle Soreness Begins with a Transient Neural Switch.International journal of molecular sciences · 2025Review
- Review
- Validation of the Ocular Pain Assessment Survey Instrument With Rasch Analysis.Translational vision science & technology · 2025Article
- Dry eye disease and psychosomatics-benefits of mind-body therapy for dry eye disease.Frontiers in medicine · 2025Review
- A Novel Quaternary Ammonium N-Propylamiodarone Bromide Provides Long-Lasting Analgesia Against Corneal Pain.Drug design, development and therapy · 2024Article
- Chronic pain in the elderly: Exploring cellular and molecular mechanisms and therapeutic perspectives.Frontiers in aging · 2024Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent ocular pain caused by corneal inflammation and/or nerve injury is accompanied by significant alterations along the pain axis. Both primary sensory neurons in the trigeminal nerves and secondary neurons in the spinal trigeminal nucleus are subjected to profound morphological and functional changes, leading to peripheral and central pain sensitization. Several studies using animal models of inflammatory and neuropathic ocular pain have provided insight about the mechanisms involved in these maladaptive changes. Recently, the advent of new techniques such as optogenetics or genetic neuronal labelling has allowed the investigation of identified circuits involved in nociception, both at the spinal and trigeminal level. In this review, we will describe some of the mechanisms that contribute to the perception of ocular pain at the periphery and at the spinal trigeminal nucleus. Recent advances in the discovery of molecular and cellular mechanisms contributing to peripheral and central pain sensitization of the trigeminal pathways will be also presented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.