ArticleFrontiers in aging neuroscience2021
Characteristics of Autonomic Dysfunction in Parkinson's Disease: A Large Chinese Multicenter Cohort Study.
Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The effect of different exercise training modes on improving quality of life in patients with Parkinson's disease: a network analysis.Frontiers in neurology · 2025Pooled it
- Mitochondrial dysfunction in sleep deprivation.Metabolic brain disease · 2026Review
- Association between anxiety, depression, and fatigue in elderly patients with Parkinson's disease.World journal of psychiatry · 2026Article
- Dementia with Lewy bodies and Parkinson disease dementia - the same or different and is it important?Nature reviews. Neurology · 2025Review
- Redefining Non-Motor Symptoms in Parkinson's Disease.Journal of personalized medicine · 2025Review
- Nonmotor Symptoms Differ Between Essential Tremor and Tremor-Dominant Parkinson's Disease.Brain and behavior · 2025Article
- Implications of heart rate variability measured using wearable electrocardiogram devices in diagnosing Parkinson's disease and its association with neuroimaging biomarkers: a case-control study.Frontiers in aging neuroscience · 2025Article
- Association between autonomic dysfunction with motor and non-motor symptoms in patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Baseline prevalence and longitudinal assessment of autonomic dysfunction in early Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China.Aging and disease · 2023Article
- Escalating Bi-Directional Feedback Loops between Proinflammatory Microglia and Mitochondria in Ageing and Post-Diagnosis of Parkinson's Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Parkinson's Disease: Diagnostic Challenges Amidst Transdiagnostic and Overlapping Mental Health Symptoms.Cureus · 2023Article
- Characteristics of fatigue in Parkinson's disease: A longitudinal cohort study.Frontiers in aging neuroscience · 2023Article
- Factors contributing to sleep disturbances and excessive daytime sleepiness in patients with Parkinson's disease.Frontiers in neurology · 2023Article
- Characteristics of autonomic dysfunction in neuronal intranuclear inclusion disease.Frontiers in neurology · 2023Article
- Cardiovascular dysautonomia and cognitive impairment in Parkinson's disease (Review).Medicine internationalReview
- Epidemiology of autonomic dysfunction in Parkinson's disease (Review).Medicine internationalReview
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autonomic dysfunction (AutD) is one of the non-motor symptoms (NMSs) in Parkinson's disease (PD). To investigate the prevalence and clinical features of AutD in Chinese patients with PD, a large multicenter cohort of 2,556 individuals with PD were consecutively involved in the Parkinson's Disease and Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC) between January 1, 2017, and December 31, 2019. The assessment of AutD was performed using the Scale for Outcomes in Parkinson's Disease for Autonomic Symptoms (SCOPA-AUT). The evaluation of motor symptoms and other NMSs were performed using well-established scales recommended by the Movement Disorder Society. We found that out of 2,556 patients with PD, 2,333 patients with PD (91.28%) had AutD. Compared with the group of patients with PD without AutD, the group of patients with PD with AutD had older age, older age of onset, longer disease duration, more severe motor symptoms, motor complications, and more frequent NMSs. As for partial correlation analysis, the total SCOPA-AUT score was significantly and positively associated with motor severity scales [Unified Parkinson's Disease Rating Scale (UPDRS) total score] and some of the NMSs [Rapid Eye Movement Sleep Behavior Disorder Questionnaire (RBD), Epworth Sleepiness Scale, Hamilton Depression Scale], Fatigue Severity Scale, and Parkinson's disease questionnaire. PD Sleep Scale was significantly and negatively correlated with AutD. With logistic regression analysis for potentially related factors, age, UPDRS total score, RBD, hyposmia, depression, and fatigue may be associated with PD with AutD. In conclusion, our multicenter cohort study reported the high prevalence of AutD in Chinese PD and revealed the associated factors of PD with AutD.
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