ReviewFrontiers in cellular neuroscience2021
The Causes and Long-Term Consequences of Viral Encephalitis.
Review in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Clinical and Laboratory Predictors of Poor Neurological Outcomes Following Infectious Encephalitis: Systematic Review and Meta-Analysis.European journal of neurology · 2025Pooled it
- Neurological sequelae after encephalitis associated with herpes simplex virus in children: systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- Peripheral human mAb therapy yields modulation of neuroinflammation and long-term functional recovery from lyssavirus infection.Emerging microbes & infections · 2026Article
- [Autoimmune encephalitis in intensive care medicine : Differentiation from infectious encephalitis].Die Anaesthesiologie · 2026Review
- Long-term outcomes of childhood encephalitis in Australia: burden and predictors from the Australian childhood encephalitis (ACE) prospective multicentre cohort.The Lancet regional health. Western Pacific · 2026Article
- Early Summer Meningoencephalitis: Unusual yet Usual Diagnostic Challenge in a Geriatric Patient-A Case Report.Reports (MDPI) · 2026Article
- A human cerebral organoid model of West Nile virus encephalitis shows innate immunocompetency.Nature communications · 2026Article
- Layer-Specific Astrocyte Morphological Responses in the CA3 Hippocampus Region During Piry Virus-Induced Encephalitis.Hippocampus · 2026Article
- Rift Valley fever virus activates multiple cell death pathways in neurons.Journal of virology · 2026Article
- Hospitalizations associated with endemic and non-endemic mosquito-borne arboviruses in Canada, 2002-2023.PloS one · 2026Article
- [Infectious and inflammatory diseases of the central nervous system 2014-2024].Revista medica del Instituto Mexicano del Seguro Social · 2026Observational
- Scalp Acupuncture for Wakefulness in Comatose Child with Acute Viral Encephalitis: A Case Report.Chinese journal of integrative medicine · 2025Article
- Cerebrolysin treatment in a case of post-herpes simplex encephalitis with neuropsychiatric symptoms.Journal of medicine and life · 2025Article
- Hamsters with long COVID present distinct transcriptomic profiles associated with neurodegenerative processes in brainstem.Nature communications · 2025Article
- Clinical Spectrum and Dynamics of Sequelae Following Tick-Borne Encephalitis Virus Infection: A Systematic Literature Review.Open forum infectious diseases · 2025Article
- Approach and overview of autoimmune encephalitis: A review.Medicine · 2025Review
- Article
- In vitro susceptibility of differentiated SH-SY5Y human neuroblastoma cells to herpes simplex virus type 1 and Japanese encephalitis virus infection.The Journal of veterinary medical science · 2025Article
- Age-Stratified Treg Responses During Viral Infections of the Central Nervous System: A Literature Review.Journal of medical virology · 2025Review
- Post-infectious central nervous system vasculitides in adults: an underdiagnosed and treatable disease : Part I. Overview.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reports regarding brain inflammation, known as encephalitis, have shown an increasing frequency during the past years. Encephalitis is a relevant concern to public health due to its high morbidity and mortality. Infectious or autoimmune diseases are the most common cause of encephalitis. The clinical symptoms of this pathology can vary depending on the brain zone affected, with mild ones such as fever, headache, confusion, and stiff neck, or severe ones, such as seizures, weakness, hallucinations, and coma, among others. Encephalitis can affect individuals of all ages, but it is frequently observed in pediatric and elderly populations, and the most common causes are viral infections. Several viral agents have been described to induce encephalitis, such as arboviruses, rhabdoviruses, enteroviruses, herpesviruses, retroviruses, orthomyxoviruses, orthopneumovirus, and coronaviruses, among others. Once a neurotropic virus reaches the brain parenchyma, the resident cells such as neurons, astrocytes, and microglia, can be infected, promoting the secretion of pro-inflammatory molecules and the subsequent immune cell infiltration that leads to brain damage. After resolving the viral infection, the local immune response can remain active, contributing to long-term neuropsychiatric disorders, neurocognitive impairment, and degenerative diseases. In this article, we will discuss how viruses can reach the brain, the impact of viral encephalitis on brain function, and we will focus especially on the neurocognitive sequelae reported even after viral clearance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.