ArticleFrontiers in neuroscience2021
Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Deep Learning-Derived Retinal Vascular Morphology and Incident Treatment for Sight-Threatening Diabetic Retinopathy.Ophthalmology science · 2026Article
- Opposing end-node and junction-node remodeling patterns in diabetic patients on optical coherence tomography angiography.Scientific reports · 2026Article
- Effect of long-term silicone oil tamponade on the density of blood vessels in the macular and peripapillary region in patients with rhegmatogenous retinal detachment.International ophthalmology · 2025Article
- The relationship between ON-OFF function and OCT structural and angiographic parameters in early diabetic retinal disease.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Characterization and Automatic Discrimination between Predominant Hypoperfusion and Hyperperfusion Stages of NPDR.Journal of personalized medicine · 2024Article
- Patterns of Progression of Nonproliferative Diabetic Retinopathy Using Non-Invasive Imaging.Translational vision science & technology · 2024Article
- Optical Coherence Tomography Angiography as a Diagnostic Tool for Diabetic Retinopathy.Diagnostics (Basel, Switzerland) · 2024Review
- Optical Coherence Tomography Angiography: Investigating Vessel Density Changes Induced by Caffeine in Healthy Subjects.Journal of ophthalmology · 2024Article
- Early diagnosis of retinal neurovascular injury in diabetic patients without retinopathy by quantitative analysis of OCT and OCTA.Acta diabetologica · 2023Observational
- Reliability of Optical Coherence Tomography Angiography Retinal Blood Flow Analyses.Translational vision science & technology · 2023Observational
- Proliferative Diabetic Retinopathy Diagnosis Using Varying-Scales Filter Banks and Double-Layered Thresholding.Diagnostics (Basel, Switzerland) · 2023Article
- Different Risk Profiles for Progression of Nonproliferative Diabetic Retinopathy: A 2-Year Study.Ophthalmology and therapy · 2023Article
- Predicting Progression to Vision-Threatening Complications in Diabetic Retinopathy.Ophthalmology scienceArticle
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3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal vessel metrics identifying microvascular changes such as vessel closure (VC) have shown potential clinical value by identifying eyes with diabetic retinopathy (DR) at different severity levels and at increased risk for disease progression to more severe stages. We compare the performance of 11 different metrics, which include 2 metrics supplied by the manufacturer, based on OCTA for identification of VC in different Early Treatment for Diabetic Retinopathy Study (ETDRS) severity groups. OCTA en-face slabs from 84 healthy eyes (70 ± 4.8 years) and 78 eyes of diabetic individuals (67 ± 7.5 years) were processed using different methods that include abnormal intercapillary spaces (AIS), vessel density (VD), and nine metrics extracted from the en-face slab. The best separation between the eyes with DR and the control group was obtained in the superficial capillary plexus (SCP), with the full retina (FR) also performing well. In the SCP, the metrics that show better performance were the AIS and the VD with a value of area under curve (AUC) equal to 0.89 [95% CI 0.84-0.94] and 0.85 [95% CI 0.79-0.91], respectively, indicating that the VD metric supported by the manufacturer is satisfactory. The values of these metrics on the different ETDRS groups show a progressive increase in VC, which is correlated with disease severity.
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