Evidence map›Paper›PMID 34916884›Full record

ArticleAmerican journal of lifestyle medicine

Rising Plasma Beta-Carotene Is Associated With Diminishing C-Reactive Protein in Patients Consuming a Dark Green Leafy Vegetable-Rich, Low Inflammatory Foods Everyday (LIFE) Diet.

Hannah Schultz, Gui-Shuang Ying, Joshua L Dunaief, David M Dunaief

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in American journal of lifestyle medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07138573 (Evaluation and Comparison of the Acute Effects of Kinesio Taping Applied to the Knee and Ankle in the Lower Extremity on Balance, Proprioception, and Anterior Cruciate Ligament Injury Risk Using the Landing Error Scoring System), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07138573 nanot yet recruitingnot on this map

Evaluation and Comparison of the Acute Effects of Kinesio Taping Applied to the Knee and Ankle in the Lower Extremity on Balance, Proprioception, and Anterior Cruciate Ligament Injury Risk Using the Landing Error Scoring System (LESS)

TypeinterventionalSponsorTokat Gaziosmanpasa UniversityRan2025 to 2025Enrolled24ConditionsACL Injury, Kinesiotape, Balance, ProprioceptionArmsKinesio Taping (KT) applied to the knee then ankle, Kinesio Taping (KT) applied to the ankle then knee
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hannah SchultzF.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.ORCID https://orcid.org/0000-0002-2392-4578
Gui-Shuang YingDepartment of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Joshua L DunaiefF.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
David M DunaiefMedical Compass MD, Brooklyn, New York.
Penn Presbyterian Medical Center · USCompass Oncology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammation contributes to a number of chronic diseases and can be assessed with C-reactive protein (CRP). In this longitudinal retrospective chart review, we investigate whether patients intensively counseled to eat a specific diet high in dark green leafy vegetables, and thus high beta-carotene, have reductions in plasma high-sensitivity CRP (hsCRP). We term this the Low Inflammatory Foods Everyday (LIFE) diet. Forty-three patients in a community practice instructed to eat the LIFE diet met inclusion criteria. The CRP levels were measured at least twice over the course of up to a year. Adherence to the diet was objectively assessed by measurement of plasma beta-carotene, which is abundant in dark green leafy vegetables, and subjectively by serial interviews. The change in beta-carotene was inversely correlated with change in CRP (

Indexed as

beta-caroteneC-reactive protein (CRP)dark green leafy vegetables (DGLV)phytonutrientswhole food plant-based diet (WFPBD)

Identifiers

PMID34916884
PMCPMC8669909
OpenAlexW2996348954

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.