Evidence map›Paper›PMID 34916808›Full record

ArticleOncoTargets and therapy2021

Effective Disease Control After Combinatorial Treatment with a PD-1 Antibody and an mTOR Inhibitor for Recurrent Ovarian Clear Cell Carcinomas: A Case Report and Literature Review.

Yue Li, Wentao Liu, Xiaoyan Zhang, Yu Fang, Xiaolong Yue, Xin Zhang, Qifan He, Na Fu, Sizhen Wang, Tonghui Ma and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in OncoTargets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yue Li *Oncology Department, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.
Wentao Liu *Oncology Department, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.
Xiaoyan Zhang *Department of Translational Medicine, Genetron Health (Beijing) Technology, Co. Ltd., Beijing, People's Republic of China.
Yu FangDepartment of Translational Medicine, Genetron Health (Beijing) Technology, Co. Ltd., Beijing, People's Republic of China.
Xiaolong YueOncology Department, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.
Xin ZhangDepartment of Translational Medicine, Genetron Health (Beijing) Technology, Co. Ltd., Beijing, People's Republic of China.
Qifan HeDepartment of Translational Medicine, Genetron Health (Beijing) Technology, Co. Ltd., Beijing, People's Republic of China.
Na FuOncology Department, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.
Sizhen WangDepartment of Translational Medicine, Genetron Health (Beijing) Technology, Co. Ltd., Beijing, People's Republic of China.
Tonghui MaDepartment of Translational Medicine, Genetron Health (Beijing) Technology, Co. Ltd., Beijing, People's Republic of China.
Dalin LiOncology Department, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.
Annoroad Gene Technology (China) · CNHarbin Medical University · CNThird Affiliated Hospital of Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian clear cell carcinoma (OCCC) is a rare type of epithelial ovarian cancer characterized by a chemoresistant phenotype and high-grade tumor. Conventional therapies for OCCC include surgery and chemotherapy. However, these OCCC treatment approaches are characterized by a high risk of relapse and drug resistance resulting in poor prognosis. Therefore, alternative therapeutic approaches are required to achieve better outcomes. In this study, a

Indexed as

everolimushigh PD-L1 expressionovarian clear cell carcinomaPIK3CA mutationtoripalimab

Identifiers

PMID34916808
PMCPMC8668246
OpenAlexW4200395316

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.