Evidence map›Paper›PMID 34916664›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2022

Distribution and maturation state of peripheral blood dendritic cells in children with primary hypertension.

Izabela Kubiszewska, Lidia Gackowska, Łukasz Obrycki, Aldona Wierzbicka, Anna Helmin-Basa, Zbigniew Kułaga, Małgorzta Wiese-Szadkowska, Jacek Michałkiewicz, Mieczysław Litwin

Abstract read
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In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Recent advances on immunity and hypertension: the new cells on the kidney block.American journal of physiology. Renal physiology · 2025
    Review
  5. Further development in the trees of the immune system is expected to elucidate the mechanisms of blood pressure elevation.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  6. Pathophysiology of primary hypertension in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2024
    Review
  7. Article
  8. Immunometabolism at the Heart of Cardiovascular Disease.JACC. Basic to translational science · 2023
    Review
  9. A new face among our Associate Editors.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Izabela Kubiszewska *Department of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland.
Lidia Gackowska *Department of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland.
Łukasz ObryckiDepartment of Nephrology, Kidney Transplantation and Arterial Hypertension, The Children's Memorial Health Institute, Warsaw, Poland.
Aldona WierzbickaDepartment of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland.
Anna Helmin-BasaDepartment of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland.
Zbigniew KułagaDepartment of Public Health, The Children's Memorial Health Institute, Warsaw, Poland.
Małgorzta Wiese-SzadkowskaDepartment of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland.
Jacek MichałkiewiczDepartment of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland.
Mieczysław LitwinDepartment of Nephrology, Kidney Transplantation and Arterial Hypertension, The Children's Memorial Health Institute, Warsaw, Poland. m.litwin@ipczd.pl.
Children's Memorial Health Institute · PLCollegium Medicum in Bydgoszcz · PLNicolaus Copernicus University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) play an important role in T cell alterations in primary hypertension (PH). We determined the numbers and maturation markers of peripheral blood total DCs (tDCs), myeloid cells (mDCs), and plasmacytoid cells (pDCs) and their association with hypertension-mediated organ damage (HMOD) markers and selected immune parameters in 30 adolescents with white coat hypertension (WCH), 25 adolescents with PH and a group of 35 age- and sex-matched children with normotension. Using multicolor flow cytometry, expression of maturation markers (CD86 and CD83) in tDCs (Lin1

Indexed as

HypertensionPulse Wave AnalysisAdolescentCarotid Intima-Media ThicknessDendritic CellsFlow CytometryHumansarterial stiffnesschildrendendritic cellslymphocyte maturationprimary hypertension

Identifiers

PMID34916664
OpenAlexW4200498098

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.