ReviewPediatric research2022
Childhood obesity and adverse cardiometabolic risk in large for gestational age infants and potential early preventive strategies: a narrative review.
Review in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- An assessment of methods for measuring body composition in full-term infants: A systematic review.Pediatric research · 2026Pooled it
- Prenatal over-the-counter acetaminophen use and birth outcomes in the ECHO Cohort.American journal of epidemiology · 2026Article
- Longitudinal Effectiveness of Repeated Lifestyle Education in Pediatric Dyslipidemia: Developmental and Environmental Modifiers in a Real-World Clinical Cohort.Children (Basel, Switzerland) · 2026Article
- First-Trimester Serum n-3/n-6 Fatty Acids Predict Large-for-Gestational-Age Risk: A Nested Case-Control Study.Maternal & child nutrition · 2026Article
- The associations of maternal liver biomarkers in different trimesters with birth weight outcomes.Scientific reports · 2026Article
- Predictive Accuracy of Ultrasound Biometry and Maternal Factors in Identifying Large-for-Gestational-Age Neonates at 30-34 Weeks.Diagnostics (Basel, Switzerland) · 2026Article
- Comparison of Chinese and international birth weight standards in predicting early childhood growth outcomes: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Gestational diabetes mellitus-induced adipokine dysregulation and links to metabolic programming risks.Frontiers in endocrinology · 2026Observational
- Fluid intake in term and preterm infants exposed to maternal diabetes.Academia nutrition and dietetics · 2026Article
- Adipose Tissue-Derived Extracellular Vesicle MicroRNAs: Diagnostic Biomarkers for the Pathophysiology Associated with Obesity.Precision chemistry · 2025Review
- Impact of Serum Retinol-binding Protein 4 Levels in Late Pregnancy on the Incidence of Small/Large for Gestational Age Infants Among 11,854 Pregnant Women: A Retrospective Study.Journal of epidemiology · 2025Article
- Association Between Maternal Creatinine to Body Weight Ratio and Small/Large for Gestational Age Newborns Among 11,734 Chinese Women.Journal of epidemiology and global health · 2025Observational
- Establishment of a risk prediction model for large-for-gestational-age infants among Chinese women with gestational diabetes mellitus.Scientific reports · 2025Article
- Alkaline phosphatase of late pregnancy promotes the prediction of adverse birth outcomes.Journal of global health · 2025Observational
- Macrosomia and Childhood Growth Trajectories From Birth to 10 Years of Age: Findings From the ROLO Longitudinal Birth Cohort Study.Journal of obesity · 2025Article
- Serum triglyceride to high density lipoprotein cholesterol ratio in late pregnancy as a potential predictor of adverse birth outcomes: an analysis of real-world data.Diabetology & metabolic syndrome · 2024Article
- Body composition and motor function in children born large for gestational age at term.Pediatric research · 2024Article
- Breastfeeding, Gestational Diabetes Mellitus, Size at Birth and Overweight/Obesity in Early Childhood.Nutrients · 2024Article
- Maternal fibrinogen/fibrin degradation products to high density lipoprotein cholesterol ratio for predicting delivery of small and large for gestational age infants: a pilot study.Lipids in health and disease · 2023Article
- Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study.Environmental health : a global access science source · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence indicates that obesity and cardiometabolic risks become established early in life due to developmental programming and infants born as large for gestational age (LGA) are particularly at risk. This review summarizes the recent literature connecting LGA infants and early childhood obesity and cardiometabolic risk and explores potential preventive interventions in early infancy. With the rising obesity rates in women of childbearing age, the LGA birth rate is about 10%. Recent literature continues to support the higher rates of obesity in LGA infants. However, there is a knowledge gap for their lifetime risk for adverse cardiometabolic outcomes. Potential factors that may modify the risk in early infancy include catch-down early postnatal growth, reduction in body fat growth trajectory, longer breastfeeding duration, and presence of a healthy gut microbiome. The early postnatal period may be a critical window of opportunity for active interventions to mitigate or prevent obesity and potential adverse metabolic consequences in later life. A variety of promising candidate biomarkers for the early identification of metabolic alterations in LGA infants is also discussed. IMPACT: LGA infants are the greatest risk category for future obesity, especially if they experience rapid postnatal growth during infancy. Potential risk modifying secondary prevention strategies in early infancy in LGA infants include catch-down early postnatal growth, reduction in body fat growth trajectory, longer breastfeeding duration, and presence of a healthy gut microbiome. LGA infants may be potential low-hanging fruit targets for early preventive interventions in the fight against childhood obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.