Evidence map›Paper›PMID 34916620›Full record

ArticleNature chemical biology2022

Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers.

Jinghua Ge, Xin Bian, Lu Ma, Yiying Cai, Yanghui Li, Jie Yang, Erdem Karatekin, Pietro De Camilli, Yongli Zhang

Open access · greenAbstract read
In one paragraph

Article in Nature chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Stay in touch with the endoplasmic reticulum.Science China. Life sciences · 2024
    Pooled it
  2. Review
  3. Article
  4. Article
  5. The Extended Synaptotagmins ofPlants (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Review
  8. DNA-Assisted Assays for Studying Lipid Transfer Between Membranes.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Quantitative Models of Lipid Transfer and Membrane Contact Formation.Contact (Thousand Oaks (Ventura County, Calif.)) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Jinghua Ge *Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5820-1521
Xin Bian *Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.
Lu Ma *Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.
Yiying Cai *Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-8363-2633
Yanghui Li *Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.
Jie YangDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-3522-0906
Erdem KaratekinDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5934-8728
Pietro De CamilliDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-9045-0723
Yongli ZhangDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT, USA. yongli.zhang@yale.edu.ORCID http://orcid.org/0000-0001-7079-7973
Yale University · USHoward Hughes Medical Institute · USCentre National de la Recherche Scientifique · FRChinese Academy of Sciences · CN

Funding

Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI ANGUS C. NAIRN, Kenneth Robert WILLIAMS · 2004 to 2026
$37.1M
Single-molecule studies of SNARE assembly and lipid transferR35GM131714 · NIGMS · YALE UNIVERSITY · PI Yongli Zhang · 2019 to 2026
$5.0M
MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLINGR01NS036251 · NINDS · YALE UNIVERSITY · PI DE CAMILLI, PIETRO · 1997 to 2021
$4.7M
Single-molecule manipulation of SNAREsR01GM093341 · NIGMS · YALE UNIVERSITY · PI ZHANG, YONGLI · 2010 to 2018
$3.1M
Molecular Mechanisms in Synaptic Vesicle RecyclingR37NS036251 · NINDS · YALE UNIVERSITY · PI DE CAMILLI, PIETRO · 2010 to 2016
$2.7M
Nucleation and dynamics of exocytotic fusion poresR01NS113236 · NINDS · YALE UNIVERSITY · PI KARATEKIN, ERDEM · 2019 to 2023
$1.8M
Common role of Sec1p/Munc18 proteins in SNARE assembly and membrane fusionR01GM120193 · NIGMS · YALE UNIVERSITY · PI ZHANG, YONGLI · 2017 to 2018
$709k
Howard Hughes Medical InstituteNIDA NIH HHS P30 DA018343NIGMS NIH HHS R01 GM093341NIGMS NIH HHS R01 GM120193NIGMS NIH HHS R35 GM131714NINDS NIH HHS R01 NS036251NINDS NIH HHS R01 NS113236NINDS NIH HHS R37 NS036251
6 · The paper itself

Abstract

Extended synaptotagmins (E-Syts) mediate lipid exchange between the endoplasmic reticulum (ER) and the plasma membrane (PM). Anchored on the ER, E-Syts bind the PM via an array of C2 domains in a Ca

Indexed as

CalciumOptical TweezersCell MembraneEndoplasmic ReticulumLipidsCalciumLipids

Identifiers

PMID34916620
PMCPMC8891060
OpenAlexW4200062817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.