Evidence map›Paper›PMID 34916557›Full record

ArticleScientific reports2021

Thyroid hormone receptor alpha sumoylation modulates white adipose tissue stores.

Yan-Yun Liu, Jingjing Jiang, Sujie Ke, Anna Milanesi, Kiyomi Abe, Gilberto Gastelum, Jianrong Li, Gregory A Brent

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. RNA Sequencing Reveals a Strong Predominance ofInternational journal of molecular sciences · 2024
    Article
  3. TRα2-An Untuned Second Fiddle or Fine-Tuning Thyroid Hormone Action?International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Yan-Yun LiuDivision of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA. yyl@g.ucla.edu.
Jingjing JiangDivision of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA.
Sujie KeDivision of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA.
Anna MilanesiDivision of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA.
Kiyomi AbeDivision of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA.
Gilberto GastelumDivision of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA.
Jianrong LiDivision of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA.
Gregory A BrentDivision of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA. gbrent@mednet.ucla.edu.
VA Greater Los Angeles Healthcare System · USFudan University · CNKeio University · JP

Funding

Thyroid Hormone Receptor Isoform-Specific ActionsR01DK067233 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRENT, GREGORY A · 2004 to 2008
$1.4M
Thyroid Hormone Receptor Isoform-Specific ActionsR01DK098576 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRENT, GREGORY A · 2014 to 2017
$1.3M
Thyroid Hormone and Retinoic Acid Regulation of Gene ExpressionI01BX001966 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI BRENT, GREGORY A · 2014 to 2025
–
BLRD VA I01 BX001966NIDDK NIH HHS R01 DK067233NIDDK NIH HHS R01 DK098576
6 · The paper itself

Abstract

Thyroid hormone (TH) and thyroid hormone receptor (THR) regulate stem cell proliferation and differentiation during development, as well as during tissue renewal and repair in the adult. THR undergoes posttranslational modification by small ubiquitin-like modifier (SUMO). We generated the THRA (K283Q/K288R)

Indexed as

AdipocytesAdipose Tissue, WhiteAnimalsCell ProliferationCREB-Binding ProteinDiet, High-FatHumansMiceMice, Mutant StrainsSmall Ubiquitin-Related Modifier ProteinsSumoylationThyroid Hormone Receptors alphaCREB-Binding ProteinSmall Ubiquitin-Related Modifier ProteinsThyroid Hormone Receptors alpha

Identifiers

PMID34916557
PMCPMC8677787
OpenAlexW4200347137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.