ArticleInternational journal of oral science2021
The vicK gene of Streptococcus mutans mediates its cariogenicity via exopolysaccharides metabolism.
Article in International journal of oral science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Molecular Regulation of Virulence and Dental Biofilm Formation in Streptococcus mutans: Unravelling the Crosstalk Between the VicRK and LiaSR Two-Component Systems.Molecular oral microbiology · 2026Review
- [The Oral Microbiome: Maintenance of Homeostasis, Disease Associations, and Mechanisms of Pathogenesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Microbiome in adult severe caries and cross-kingdom biofilms validation.Clinical oral investigations · 2026Article
- [Oral Health Status of Obese Children andIntervention Strategies].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- Buprenorphine enhancesJournal of oral microbiology · 2026Article
- Effect ofAmerican journal of translational research · 2026Article
- Overexpression of ASFrontiers in cellular and infection microbiology · 2026Article
- AdcBC-dependent zinc uptake influences physiological responses inJournal of oral microbiology · 2026Article
- Feasibility of salivary lipid screening for caries biomarkers in young adults.BMC oral health · 2025Article
- Sodium houttuyfonate inhibits the cariogenic virulence ofJournal of oral microbiology · 2025Article
- A bacterial sensor taxonomy across earth ecosystems for machine learning applications.mSystems · 2024Article
- Unveiling the complexity of early childhood caries:Journal of oral microbiology · 2024Review
- Effects of caffeic acid phenethyl ester against multi-species cariogenic biofilms.Folia microbiologica · 2023Article
- Multifunctional magnesium organic framework-based photothermal and pH dual-responsive mouthguard for caries prevention and tooth self-healing promotion.Bioactive materials · 2023Article
- Postbiotics Derived fromMolecules (Basel, Switzerland) · 2023Article
- Antimicrobial peptide temporin derivatives inhibit biofilm formation and virulence factor expression ofFrontiers in microbiology · 2023Article
- Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans.Journal of oral microbiology · 2023Review
- Exopolysaccharides metabolism and cariogenesis ofJournal of oral microbiology · 2023Article
- Exploiting Conserved Quorum Sensing Signals in Streptococcus mutans and Streptococcus pneumoniaeMicroorganisms · 2022Article
- Candida albicans CHK1 gene regulates its cross-kingdom interactions with Streptococcus mutans to promote caries.Applied microbiology and biotechnology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus mutans (S. mutans) is generally regarded as a major contributor to dental caries because of its ability to synthesize extracellular polysaccharides (EPS) that aid in the formation of plaque biofilm. The VicRKX system of S. mutans plays an important role in biofilm formation. The aim of this study was to investigate the effects of vicK gene on specific characteristics of EPS in S. mutans biofilm. We constructed single-species biofilms formed by different mutants of vicK gene. Production and distribution of EPS were detected through atomic force microscopy, scanning electron microscopy and confocal laser scanning microscopy. Microcosmic structures of EPS were analyzed by gel permeation chromatography and gas chromatography-mass spectrometry. Cariogenicity of the vicK mutant was assessed in a specific pathogen-free rat model. Transcriptional levels of cariogenicity-associated genes were confirmed by quantitative real-time polymerase chain reaction. The results showed that deletion of vicK gene suppressed biofilm formation as well as EPS production, and EPS were synthesized mostly around the cells. Molecular weight and monosaccharide components underwent evident alterations. Biofilms formed in vivo were sparse and contributed a decreased degree of caries. Moreover, expressional levels of genes related to EPS synthesis were down-regulated, except for gtfB. Our report demonstrates that vicK gene enhances biofilm formation and subsequent caries development. And this may due to its regulations on EPS metabolism, like synthesis or microcosmic features of EPS. This study suggests that vicK gene and EPS can be considered as promising targets to modulate dental caries.
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