Evidence map›Paper›PMID 34916446›Full record

ArticleNeural regeneration research2022

Lutein delays photoreceptor degeneration in a mouse model of retinitis pigmentosa.

Hui-Jun Zhang, Xiao-Bin Liu, Xiong-Min Chen, Qi-Hang Kong, Yu-Sang Liu, Kwok-Fai So, Jian-Su Chen, Ying Xu, Xue-Song Mi, Shi-Bo Tang

Open access · goldAbstract read
In one paragraph

Article in Neural regeneration research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hui-Jun ZhangDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University; Department of Ophthalmology, Guangzhou Panyu Central Hospital, Guangzhou, Guangdong Province, China.
Xiao-Bin LiuGuangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China.
Xiong-Min ChenGuangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China.
Qi-Hang KongDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China.
Yu-Sang LiuGuangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China.
Kwok-Fai SoGuangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province; Aier Academician Station, Changsha, Hunan Province; Key Laboratory of CNS Regeneration (Jinan University), Ministry of Education, Guangzhou, Guangdong Province; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China.
Jian-Su ChenDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province; Laboratory of Retinal Cell Biology, Aier Eye Institute; Aier Academician Station, Changsha, Hunan Province, China.
Ying XuGuangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province; Aier Academician Station, Changsha, Hunan Province; Key Laboratory of CNS Regeneration (Jinan University), Ministry of Education, Guangzhou, Guangdong Province; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China.
Xue-Song MiDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province; Aier Academician Station, Changsha, Hunan Province, China.
Shi-Bo TangLaboratory of Retinal Cell Biology, Aier Eye Institute; Aier Academician Station, Changsha, Hunan Province, China.
Jinan University · CNFirst Affiliated Hospital of Jinan University · CNNantong University · CNPanyu District Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinitis pigmentosa is a retinal disease characterized by photoreceptor degeneration. There is currently no effective treatment for retinitis pigmentosa. Although a mixture of lutein and other antioxidant agents has shown promising effects in protecting the retina from degeneration, the role of lutein alone remains unclear. In this study, we administered intragastric lutein to Pde6b

Indexed as

anti-inflammationglial fibrillary acidic proteinluteinmicrogliaPde6brd10photoreceptor(rd10) mousereactive gliosisretinal degenerationretinal diseaseretinitis pigmentosa

Identifiers

PMID34916446
PMCPMC8771084
OpenAlexW4200003619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.