ArticleNeural regeneration research2022
Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up.
Article in Neural regeneration research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Long-Term Consequences of COVID-19 at 6 Months and Above: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Investigation of BOLD signal intensities in long COVID patients using 7T functional MRI.Brain, behavior, & immunity - health · 2026Article
- Dynamic recovery of piriform cortex function and its impact on cognitive processing speed following mild COVID-19.BMC neurology · 2026Article
- Altered cortical neuronal activity in functional esophageal disorders and its associations with chronic insomnia and peripheral inflammation: a resting-state fMRI study.Frontiers in molecular neuroscience · 2026Article
- Altered static and dynamic intrinsic brain activity patterns in type 2 diabetic patients.Scientific reports · 2025Article
- Decreases in frequency-dependent intrinsic activity of the default mode network are associated with depression and cognition in patients with postacute sequelae of SARS-CoV-2 infection.Brain structure & function · 2025Article
- The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men.BMC infectious diseases · 2025Article
- Article
- Systematic review and meta-analysis of brain neuroimaging abnormalities in COVID-19 patients and survivors.Psychoradiology · 2025Article
- Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study.Nature and science of sleep · 2025Article
- Causal effect of COVID-19 on longitudinal volumetric changes in subcortical structures: A mendelian randomization study.Heliyon · 2024Article
- Multimodal neuroimaging exploration of the mechanisms of sleep quality deterioration after SARS-CoV-2 Omicron infection.BMC medicine · 2024Article
- Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study.The Lancet regional health. Western Pacific · 2024Article
- Associations between COVID-19 and putative markers of neuroinflammation: A diffusion basis spectrum imaging study.Brain, behavior, & immunity - health · 2024Article
- Comprehensive MRI assessment reveals subtle brain findings in non-hospitalized post-COVID patients with cognitive impairment.Frontiers in neuroscience · 2024Article
- Altered brain function and structure pre- and post- COVID-19 infection: a longitudinal study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Associations between COVID-19 and putative markers of neuroinflammation: A diffusion basis spectrum imaging study.bioRxiv : the preprint server for biology · 2023Article
- Gray Matter Thickness and Subcortical Nuclear Volume in Men After SARS-CoV-2 Omicron Infection.JAMA network open · 2023Article
- Epidemiology, clinical presentation, pathophysiology, and management of long COVID: an update.Molecular psychiatry · 2023Review
- In Between the Psychological and Physiological Self - The Impact of Covid-19 Pandemic on the Neuro-Socio-Ecological and Inflammatory Mind-Body-Brain System.Clinical neuropsychiatry · 2023Article
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16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although some short-term follow-up studies have found that individuals recovering from coronavirus disease 2019 (COVID-19) exhibit anxiety, depression, and altered brain microstructure, their long-term physical problems, neuropsychiatric sequelae, and changes in brain function remain unknown. This observational cohort study collected 1-year follow-up data from 22 patients who had been hospitalized with COVID-19 (8 males and 11 females, aged 54.2 ± 8.7 years). Fatigue and myalgia were persistent symptoms at the 1-year follow-up. The resting state functional magnetic resonance imaging revealed that compared with 29 healthy controls (7 males and 18 females, aged 50.5 ± 11.6 years), COVID-19 survivors had greatly increased amplitude of low-frequency fluctuation (ALFF) values in the left precentral gyrus, middle frontal gyrus, inferior frontal gyrus of operculum, inferior frontal gyrus of triangle, insula, hippocampus, parahippocampal gyrus, fusiform gyrus, postcentral gyrus, inferior parietal angular gyrus, supramarginal gyrus, angular gyrus, thalamus, middle temporal gyrus, inferior temporal gyrus, caudate, and putamen. ALFF values in the left caudate of the COVID-19 survivors were positively correlated with their Athens Insomnia Scale scores, and those in the left precentral gyrus were positively correlated with neutrophil count during hospitalization. The long-term follow-up results suggest that the ALFF in brain regions related to mood and sleep regulation were altered in COVID-19 survivors. This can help us understand the neurobiological mechanisms of COVID-19-related neuropsychiatric sequelae. This study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University (approval No. 2020S004) on March 19, 2020.
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