Evidence map›Paper›PMID 34916334›Full record

ArticleRNA (New York, N.Y.)2022

Frameshifting at collided ribosomes is modulated by elongation factor eEF3 and by integrated stress response regulators Gcn1 and Gcn20.

Lisa Houston, Evan M Platten, Sara M Connelly, Jiyu Wang, Elizabeth J Grayhack

Open access · greenAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Emerging Role of GCN1 in Disease and Homeostasis.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Inducible SystemicInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lisa HoustonDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.ORCID 0000-0002-3651-5060
Evan M PlattenDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.
Sara M ConnellyDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.
Jiyu WangDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.ORCID 0000-0002-1283-2934
Elizabeth J GrayhackDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.ORCID 0000-0003-2400-5490
University of Rochester · US

Funding

Training in Cellular, Biochemical and Molecular SciencesT32GM068411 · NIGMS · UNIVERSITY OF ROCHESTER · PI MAQUAT, LYNNE E · 2005 to 2019
$3.9M
Modulation of translation by synonymous codons in yeastR01GM118386 · NIGMS · UNIVERSITY OF ROCHESTER · PI GRAYHACK, ELIZABETH JOAN · 2016 to 2023
$2.5M
NIGMS NIH HHS R01 GM118386NIGMS NIH HHS T32 GM068411
6 · The paper itself

Abstract

Ribosome stalls can result in ribosome collisions that elicit quality control responses, one function of which is to prevent ribosome frameshifting, an activity that entails the interaction of the conserved yeast protein Mbf1 with uS3 on colliding ribosomes. However, the full spectrum of factors that mediate frameshifting during ribosome collisions is unknown. To delineate such factors in the yeast

Indexed as

Frameshifting, RibosomalPeptide Elongation FactorsSaccharomyces cerevisiae ProteinsATP-Binding Cassette TransportersSaccharomyces cerevisiaeStress, PhysiologicalTranscription FactorsUbiquitin-Protein LigasesATP-Binding Cassette TransportersGCN1 protein, S cerevisiaeGcn20 protein, S cerevisiaeHel2 protein, S cerevisiaeMBF1 protein, S cerevisiaePeptide Elongation FactorsSaccharomyces cerevisiae ProteinsTranscription FactorsUbiquitin-Protein LigasesYEF3 protein, S cerevisiaeeEF3frameshiftinggeneral amino acid controlintegrated stress responseribosome quality controltranslation

Identifiers

PMID34916334
PMCPMC8848926
OpenAlexW4220751582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.