ArticleProceedings of the National Academy of Sciences of the United States of America2021
Symmetric activation and modulation of the human calcium-sensing receptor.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
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Who cites it
37 citing papers in PubMed, 60 citations in OpenAlex.
- Time matters: circadian genetics and the molecular logic of human health and disease.Nature reviews. Genetics · 2026Review
- Integrated transcriptomic and in silico structural analysis identifies NFS1 and HSPA9 as potential regulators associated with mitochondrial ferroptosis and cell death resistance in colorectal cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Heat shock protein family D member 1 (HSPD1) modulates ribosome-related pathways and protein synthesis in lung adenocarcinoma.Molecular and cellular biochemistry · 2026Article
- Integrating non-coding RNA profiling with HPV genotyping for cervical cancer risk stratification and early detection.Molecular biology reports · 2026Review
- Molecular mechanism of p-Coumaric acid in the regulation of AQP2 function through the activation of calcium-sensing receptor signaling.Scientific reports · 2026Article
- A novel HPV E6/E7-regulated long noncoding RNA CRL suppresses cervical intraepithelial neoplasia progression by attenuating ferroptosis.Human cell · 2026Article
- Mechanistic and therapeutic insights into class A GPCR dimers in neuropsychiatric disorders.npj drug discovery · 2026Review
- Targeting frizzled receptors (FZDs) for anti-tumor therapy: From orthosteric to allosteric inhibition.Acta pharmaceutica Sinica. B · 2026Review
- Calcium-Sensing Receptor Regulation of Gastrointestinal Hormone Secretion.Endocrine reviews · 2026Review
- CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling.Nature communications · 2026Article
- Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors.Nature communications · 2025Article
- Both calcium-sensing receptor intracellular C-terminal domains support homodimer signaling.Molecular pharmacology · 2025Article
- A large-scale curated and filterable dataset for cryo-EM foundation model pre-training.Scientific data · 2025Article
- Direct effect of membrane environment on the activation of mGluR2 revealed by single-molecule FRET.Structure (London, England : 1993) · 2025Article
- A tale of detergent tails: GPCR activation beyond ligands.Structure (London, England : 1993) · 2025Article
- Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery.Nature reviews. Drug discovery · 2025Review
- PnNAC03 from Panax notoginseng functions in positively regulating saponins and lignin biosynthesis during cell wall formation.Plant cell reports · 2025Article
- An activating calcium-sensing receptor variant with biased signaling reveals a critical residue for Gα11 coupling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Cryo-EM structure of the calcium-sensing receptor complexed with the kokumi substance γ-glutamyl-valyl-glycine.Scientific reports · 2025Article
- The calcium-sensing receptor: a comprehensive review on its role in calcium homeostasis and therapeutic implications.American journal of translational research · 2025Review
Corrections and comments
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Authors and funding
29 authors at 5 institutions in 4 countries.
Jinseo ParkDepartment of Pharmacology, Columbia University, New York, NY 10032.
Hao ZuoDepartment of Pharmacology, Columbia University, New York, NY 10032.
Aurel FrangajDepartment of Pharmacology, Columbia University, New York, NY 10032.
Ziao FuDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Laura Y YenNational Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027.
Zhening ZhangDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Lidia MosyakDepartment of Pharmacology, Columbia University, New York, NY 10032.
Vesna N SlavkovichDepartment of Environmental Health Sciences, Columbia University, New York, NY 10032.
Jonathan LiuDepartment of Pharmacology, Columbia University, New York, NY 10032.
Kimberly M RayDepartment of Pharmacology, Columbia University, New York, NY 10032.
Baohua CaoDepartment of Pharmacology, Columbia University, New York, NY 10032.
Francesca ValleseDepartment of Anesthesiology, Columbia University, New York, NY 10032.
Yong GengDepartment of Pharmacology, Columbia University, New York, NY 10032.
Shaoxia ChenMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Robert GrassucciDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Venkata P DandeyNational Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027.
Yong Zi TanNational Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027.
Edward EngNational Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027.ORCID 0000-0002-8014-7269
Yeji LeeDepartment of Pharmacology, Columbia University, New York, NY 10032.
Brian KlossCenter on Membrane Protein Production and Analysis, New York Structural Biology Center, New York, NY 10027.
Zheng LiuDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Wayne A HendricksonDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032; wah2@cumc.columbia.edu arthur.conigrave@sydney.edu.au jf2192@cumc.columbia.edu oc2188@cumc.columbia.edu qf13@cumc.columbia.edu.
Clinton S PotterDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Bridget CarragherDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.ORCID 0000-0002-0624-5020
Joseph GrazianoDepartment of Environmental Health Sciences, Columbia University, New York, NY 10032.
Arthur D ConigraveSchool of Life and Environmental Sciences, Charles Perkins Centre, University of Sydney, Camperdown, NSW 2006, Australia; wah2@cumc.columbia.edu arthur.conigrave@sydney.edu.au jf2192@cumc.columbia.edu oc2188@cumc.columbia.edu qf13@cumc.columbia.edu.
Joachim FrankDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032; wah2@cumc.columbia.edu arthur.conigrave@sydney.edu.au jf2192@cumc.columbia.edu oc2188@cumc.columbia.edu qf13@cumc.columbia.edu.
Oliver B ClarkeDepartment of Anesthesiology, Columbia University, New York, NY 10032; wah2@cumc.columbia.edu arthur.conigrave@sydney.edu.au jf2192@cumc.columbia.edu oc2188@cumc.columbia.edu qf13@cumc.columbia.edu.ORCID 0000-0003-1876-196X
Qing R FanDepartment of Pharmacology, Columbia University, New York, NY 10032; wah2@cumc.columbia.edu arthur.conigrave@sydney.edu.au jf2192@cumc.columbia.edu oc2188@cumc.columbia.edu qf13@cumc.columbia.edu.ORCID 0000-0002-9330-0963
Columbia University · USNew York Structural Biology Center · USAgency for Science, Technology and Research · SGMRC Laboratory of Molecular Biology · GBThe University of Sydney · AU
Funding
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7MTRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7MTraining (303-338)P41GM116799 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI HENDRICKSON, WAYNE A. · 2016 to 2020
$7.1MSTRUCTURE ANALYSIS OF MACROMOLECULAR ASSEMBLIESR01GM029169 · NIGMS · WADSWORTH CENTER · PI FRANK, JOACHIM · 1985 to 2019
$6.1MProposal for an Administrative Supplement for Equipment Purchases for NIGMS Awardees NOT-GM-18-022R01GM107462 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENDRICKSON, WAYNE A. · 2014 to 2021
$3.6MMolecular mechanism of dimeric G protein-coupled receptor signalingR35GM141871 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QING R FAN · 2021 to 2026
$2.7MMedical Research Council MC_U105184326NIEHS NIH HHS P30 ES009089NIGMS NIH HHS P41 GM103310NIGMS NIH HHS P41 GM116799NIGMS NIH HHS R01 GM029169NIGMS NIH HHS R01 GM107462NIGMS NIH HHS R35 GM141871
Abstract
The human extracellular calcium-sensing (CaS) receptor controls plasma Ca
Indexed as
CalciumCryoelectron MicroscopyGene Expression RegulationHEK293 CellsHomeostasisHumansModels, MolecularProtein ConformationProtein DomainsReceptors, Calcium-SensingSignal TransductionCalciumReceptors, Calcium-Sensingactivation mechanismallosteric modulationcalcium-sensing receptorcryo-EM structuresymmetry
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.