Evidence map›Paper›PMID 34916279›Full record

ArticleNeurology2022

Effect of Age at Pediatric Stroke on Long-term Cognitive Outcome.

Stephanie Abgottspon, Qendresa Thaqi, Leonie Steiner, Nedelina Slavova, Sebastian Grunt, Maja Steinlin, Regula Everts

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Stephanie AbgottsponFrom the Division of Neuropediatrics, Development and Rehabilitation, Department of Pediatrics (S.A., Q.T., L.S., S.G., M.S., R.E.), Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism (S.A., R.E.), and Institute of Diagnostic and Interventional Neuroradiology (N.S.), Inselspital, Bern University Hospital, University of Bern; Graduate School for Health Sciences (S.A., L.S.) and Department of Psychology (Q.T.), University of Bern; and Pediatric Radiology (N.S.), University Children's Hospital Basel and University of Basel, Switzerland.
Qendresa ThaqiFrom the Division of Neuropediatrics, Development and Rehabilitation, Department of Pediatrics (S.A., Q.T., L.S., S.G., M.S., R.E.), Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism (S.A., R.E.), and Institute of Diagnostic and Interventional Neuroradiology (N.S.), Inselspital, Bern University Hospital, University of Bern; Graduate School for Health Sciences (S.A., L.S.) and Department of Psychology (Q.T.), University of Bern; and Pediatric Radiology (N.S.), University Children's Hospital Basel and University of Basel, Switzerland.
Leonie SteinerFrom the Division of Neuropediatrics, Development and Rehabilitation, Department of Pediatrics (S.A., Q.T., L.S., S.G., M.S., R.E.), Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism (S.A., R.E.), and Institute of Diagnostic and Interventional Neuroradiology (N.S.), Inselspital, Bern University Hospital, University of Bern; Graduate School for Health Sciences (S.A., L.S.) and Department of Psychology (Q.T.), University of Bern; and Pediatric Radiology (N.S.), University Children's Hospital Basel and University of Basel, Switzerland.
Nedelina SlavovaFrom the Division of Neuropediatrics, Development and Rehabilitation, Department of Pediatrics (S.A., Q.T., L.S., S.G., M.S., R.E.), Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism (S.A., R.E.), and Institute of Diagnostic and Interventional Neuroradiology (N.S.), Inselspital, Bern University Hospital, University of Bern; Graduate School for Health Sciences (S.A., L.S.) and Department of Psychology (Q.T.), University of Bern; and Pediatric Radiology (N.S.), University Children's Hospital Basel and University of Basel, Switzerland.
Sebastian GruntFrom the Division of Neuropediatrics, Development and Rehabilitation, Department of Pediatrics (S.A., Q.T., L.S., S.G., M.S., R.E.), Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism (S.A., R.E.), and Institute of Diagnostic and Interventional Neuroradiology (N.S.), Inselspital, Bern University Hospital, University of Bern; Graduate School for Health Sciences (S.A., L.S.) and Department of Psychology (Q.T.), University of Bern; and Pediatric Radiology (N.S.), University Children's Hospital Basel and University of Basel, Switzerland.
Maja SteinlinFrom the Division of Neuropediatrics, Development and Rehabilitation, Department of Pediatrics (S.A., Q.T., L.S., S.G., M.S., R.E.), Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism (S.A., R.E.), and Institute of Diagnostic and Interventional Neuroradiology (N.S.), Inselspital, Bern University Hospital, University of Bern; Graduate School for Health Sciences (S.A., L.S.) and Department of Psychology (Q.T.), University of Bern; and Pediatric Radiology (N.S.), University Children's Hospital Basel and University of Basel, Switzerland.
Regula EvertsFrom the Division of Neuropediatrics, Development and Rehabilitation, Department of Pediatrics (S.A., Q.T., L.S., S.G., M.S., R.E.), Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism (S.A., R.E.), and Institute of Diagnostic and Interventional Neuroradiology (N.S.), Inselspital, Bern University Hospital, University of Bern; Graduate School for Health Sciences (S.A., L.S.) and Department of Psychology (Q.T.), University of Bern; and Pediatric Radiology (N.S.), University Children's Hospital Basel and University of Basel, Switzerland. regula.evertsbrekenfeld@insel.ch.
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesTo investigate the effect of age at pediatric arterial ischemic stroke on long-term cognitive outcome in order to identify patients particularly at risk for the development of long-term cognitive sequelae.

methodsThis cross-sectional study included patients in the chronic phase of stroke (>2 years after stroke) previously diagnosed with neonatal or childhood arterial ischemic stroke and a control group. Participants with active epilepsy, severe learning difficulties, or behavioral problems hindering the cognitive assessment were excluded. Several cognitive domains, including intelligence, executive functions (working memory, inhibition, and cognitive flexibility), processing speed, memory, letter fluency, and visual-motor skills were assessed with neuropsychological tests. Cognitive long-term outcome was compared across patients after neonatal stroke (stroke between 0 and 28 days of life), early childhood stroke (stroke between 29 days and <6 years), and late childhood stroke (stroke between ≥6 and <16 years).

resultsFifty-two patients after neonatal or childhood arterial ischemic stroke (median age 15.3 years, interquartile range [IQR] 10.6-18.7) and 49 healthy controls (median age 13.6 years, IQR 9.8-17.2) met the inclusion criteria. Cognitive outcome was significantly worse in the pediatric stroke group compared to the control group. A nonlinear effect of age at stroke (irrespective of lesion size and lesion location) was found for cognitive flexibility, processing speed, and verbal learning with early childhood stroke (29 days to <6 years), showing significantly worse cognitive outcome compared to neonatal or late childhood stroke ( DISCUSSION: Age at stroke is an important factor for poststroke recovery and modulates long-term cognitive outcome irrespective of lesion size and lesion location. Children after early childhood stroke are at particular risk for long-term alterations in cognitive functions.

Indexed as

StrokeAdolescentChildChild, PreschoolCognitionCross-Sectional StudiesExecutive FunctionHumansInfant, NewbornNeuropsychological Tests

Identifiers

PMID34916279
PMCPMC8865894
OpenAlexW4200164381

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.