Evidence map›Paper›PMID 34916258›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Robo2 Drives Target-Selective Peripheral Nerve Regeneration in Response to Glia-Derived Signals.

Patricia L Murphy, Jesse Isaacman-Beck, Michael Granato

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Patricia L MurphyDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 patti.murphy@gmail.com jisaacmanbeck@gmail.com granatom@pennmedicine.upenn.edu.
Jesse Isaacman-BeckDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 patti.murphy@gmail.com jisaacmanbeck@gmail.com granatom@pennmedicine.upenn.edu.
Michael GranatoDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 patti.murphy@gmail.com jisaacmanbeck@gmail.com granatom@pennmedicine.upenn.edu.
University of Pennsylvania · US

Funding

Genetic analysis of axonal regenerationR01EY024861 · NEI · UNIVERSITY OF PENNSYLVANIA · PI GRANATO, MICHAEL · 2014 to 2023
$4.1M
Graduate Training in Developmental BiologyT32HD083185 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Michael Granato, Foteini Mourkioti · 2015 to 2026
$4.0M
Molecular genetic mechanisms of spontaneous spinal cord regenerationR01NS097914 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Michael Granato · 2017 to 2026
$3.3M
Cellular and molecular analysis of startle modulationR01NS118921 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI GRANATO, MICHAEL · 2021 to 2025
$2.6M
Cellular and molecular analysis of startle modulationR01MH109498 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GRANATO, MICHAEL · 2016 to 2020
$2.4M
Cellular and molecular mechanisms of peripheral nerve regenerationR56NS097914 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI GRANATO, MICHAEL · 2016 to 2016
$464k
Characterizing the role of robo2 in target-specific nerve regenerationF31NS103394 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MURPHY, PATRICIA L · 2017 to 2018
$50k
NEI NIH HHS R01 EY024861NICHD NIH HHS T32 HD083185NIMH NIH HHS R01 MH109498NINDS NIH HHS F31 NS103394NINDS NIH HHS R01 NS097914NINDS NIH HHS R01 NS118921NINDS NIH HHS R56 NS097914
6 · The paper itself

Abstract

Peripheral nerves are divided into multiple branches leading to divergent synaptic targets. This poses a remarkable challenge for regenerating axons as they select their original trajectory at nerve branch-points. Despite implications for functional regeneration, the molecular mechanisms underlying target selectivity are not well characterized.

Indexed as

AnimalsAnimals, Genetically ModifiedAxonsMotor NeuronsNerve RegenerationNeurogliaPeripheral NervesReceptors, ImmunologicRoundabout ProteinsZebrafishZebrafish ProteinsReceptors, Immunologicrobo2 protein, zebrafishRoundabout ProteinsZebrafish Proteinscollagen 4a5peripheral nerve regenerationrobo2schwann cellstarget selectionzebrafish

Identifiers

PMID34916258
PMCPMC8808733
OpenAlexW4226445929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.