Evidence map›Paper›PMID 34916188›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021

[Identification and validation of hub genes in prostate cancer progression based on weighted gene co-expression network analysis].

H Zhang, N Chen, X Wang, B Gao, M Ling, G Chen, Z Wu, Y Li, W Zhong, B Pan

Open access · greenAbstract read
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

H ZhangDepartment of Urology, Meizhou People's Hospital, Meizhou 514021, China.
N ChenDepartment of Urology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
X WangDepartment of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
B GaoDepartment of Urology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
M LingDepartment of Urology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
G ChenDepartment of Urology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Z WuDepartment of Urology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Y LiDepartment of Urology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
W ZhongDepartment of Urology, Guangzhou Twelfth People's Hospital, Guangzhou 510630, China.
B PanDepartment of Urology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
First Affiliated Hospital of Jinan University · CNSun Yat-sen University Cancer Center · CNMeizhou City People's Hospital · CNNanfang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify the key hub genes in prostate cancer metastasis based on weighted gene co-expression network analysis (WGCNA) and verify the identified genes.

methodsWhole-genome chip data GSE6919 of prostate cancer study were analyzed using principal component analysis (PCA), and the differentially expressed genes (DEGs) were analyzed using R software. WGCNA was performed to construct a gene co-expression network for screening the key genes. TCGA database was used to explore the expressions of the DEGs and their association with the prognosis. To validate the results, we designed siRNA fragments targeting the metastasis-related gene

resultsPCA analysis showed obvious clustering of significant DEGs in metastatic cancer group. The modules obtained by WGCNA analysis in metastasis group involved stem cell differentiation, amino acid metabolism and immune response. Further screening of the genes identified 3 genes related with prostate cancer occurrence (

conclusionWe identified 3 hub genes related with the occurrence (

Indexed as

Prostatic NeoplasmsAlcohol OxidoreductasesCo-Repressor ProteinsHeterogeneous-Nuclear Ribonucleoprotein Group A-BHumansHydroxybutyrate DehydrogenaseMaleN-Acetylglucosaminyltransferasesp21-Activated KinasesPrognosisReceptors, ImmunologicAlcohol OxidoreductasesCo-Repressor ProteinsCTBP2 protein, humanEXTL3 protein, humanHeterogeneous-Nuclear Ribonucleoprotein Group A-BhnRNP A2Hydroxybutyrate DehydrogenaseN-AcetylglucosaminyltransferasesNKTR protein, humanp21-Activated KinasesPAK4 protein, humanReceptors, Immunologichub genemetastasisprostate cancerTCGAweighted gene co-expression network analysis

Identifiers

PMID34916188
PMCPMC8685695
OpenAlexW4200249548

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