ArticleBiological psychiatry2022
Dynamic Alterations in Neural Networks Supporting Aversive Learning in Children Exposed to Trauma: Neural Mechanisms Underlying Psychopathology.
Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- How childhood adversity affects components of decision making.Neuroscience and biobehavioral reviews · 2025Pooled it
- Pooled it
- A coordinate-based meta-analysis of human amygdala connectivity alterations related to early life adversities.Scientific reports · 2023Pooled it
- Opposing sensitive period effects of early and late childhood maltreatment on corticolimbic responses in fear conditioning.Molecular psychiatry · 2026Article
- Trauma From the Eye of the Beholder: Reporter Discordance in Children's Trauma, Psychopathology, and Neurobiology.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Social circuits under developmental threat: Bridging rodent and human neuroscience.Developmental review : DR · 2025Article
- Developmental Differences in a Hippocampal-Cingulate Pathway Involved in Learned Safety Following Interpersonal Trauma Exposure.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Person-centered analyses reveal that developmental adversity at moderate levels and neural threat/safety discrimination are associated with lower anxiety in early adulthood.Communications psychology · 2025Article
- Strengthening through adversity: The hormesis model in developmental psychopathology.Development and psychopathology · 2024Article
- The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research.Molecular psychiatry · 2024Review
- Alterations in fear learning as a mechanism linking childhood exposure to violence with PTSD symptoms: a longitudinal study.Psychological medicine · 2024Article
- Neuroimmune mechanisms connecting violence with internalizing symptoms: A high-dimensional multimodal mediation analysis.Human brain mapping · 2024Article
- Stability and variation of brain-behavior correlation patterns across measures of social support.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Neural circuitry involved in conditioned inhibition via safety signal learning is sensitive to trauma exposure.Neurobiology of stress · 2022Article
- Developmental impacts of deprivation and threat on emotion recognition.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAltered aversive learning represents a potential mechanism through which childhood trauma (CT) might influence risk for psychopathology. This study examines the temporal dynamics of neural activation and patterns of functional connectivity during aversive learning in children with and without exposure to CT involving interpersonal violence and evaluates whether these neural patterns mediate the association of CT with psychopathology in a longitudinal design.
methodsA total of 147 children (aged 8-16 years, 77 with CT) completed a fear conditioning procedure during a functional magnetic resonance imaging scan. Dynamic patterns of neural activation were examined, and functional connectivity was assessed with generalized psychophysiological interaction analyses. We evaluated whether the associations between CT and psychopathology symptoms at baseline and 2-year follow-up were mediated by neural activation and connectivity during aversive learning.
resultsChildren exposed to trauma displayed blunted patterns of neural activation over time to the conditioned threat versus safety stimuli (CS+>CS-) in the right amygdala. In addition, trauma was associated with reduced functional connectivity of right amygdala with the hippocampus, posterior parahippocampal gyrus, and posterior cingulate cortex and with elevated connectivity with the anterior cingulate cortex to CS+>CS-. The longitudinal association between CT and later externalizing symptoms was mediated by blunted activation in the right amygdala. Reduced amygdala-hippocampal connectivity mediated the association of CT with transdiagnostic anxiety symptoms, and elevated amygdala-anterior cingulate cortex connectivity mediated the association of CT with generalized anxiety symptoms.
conclusionsCT is associated with poor threat-safety discrimination and altered functional coupling between salience and default mode network regions during aversive learning. These altered dynamics may be key mechanisms linking CT with distinct forms of psychopathology.
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