Evidence map›Paper›PMID 34915933›Full record

ArticleJournal of medical case reports2021

COVID-19 and chronic diabetes: the perfect storm for reactivation tuberculosis?: a case series.

Genesis P Aguillón-Durán, Ericka Prieto-Martínez, Doris Ayala, Juan García, John M Thomas, Juan Ignacio García, Brandon Michael Henry, Jordi B Torrelles, Joanne Turner, Eder Ledezma-Campos and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of medical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Impact of Social Determinants of Health on the Incidence of Tuberculosis in Central Asia.International journal of environmental research and public health · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Genesis P Aguillón-DuránSchool of Public Health, University of Texas Health Science Center at Houston, Brownsville Campus, Brownsville, TX, 78520, USA.
Ericka Prieto-MartínezSecretaria de Salud de Tamaulipas, 88630, Reynosa, Tamaulipas, Mexico.
Doris AyalaSchool of Public Health, University of Texas Health Science Center at Houston, Brownsville Campus, Brownsville, TX, 78520, USA.
Juan GarcíaDepartment of Human Genetics, South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, 1214 W Schunior, UTRGV-Edinburg Campus, Edinburg, TX, 78541, USA.
John M ThomasDepartment of Human Genetics, South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, 1214 W Schunior, UTRGV-Edinburg Campus, Edinburg, TX, 78541, USA.
Juan Ignacio GarcíaPopulation Health Program and Host Pathogens Interactions Program, Texas Biomedical Research Institute, San Antonio, TX, 78229, USA.
Brandon Michael HenryPopulation Health Program and Host Pathogens Interactions Program, Texas Biomedical Research Institute, San Antonio, TX, 78229, USA.
Jordi B TorrellesPopulation Health Program and Host Pathogens Interactions Program, Texas Biomedical Research Institute, San Antonio, TX, 78229, USA.
Joanne TurnerPopulation Health Program and Host Pathogens Interactions Program, Texas Biomedical Research Institute, San Antonio, TX, 78229, USA.
Eder Ledezma-CamposDepartment of Human Genetics, South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, 1214 W Schunior, UTRGV-Edinburg Campus, Edinburg, TX, 78541, USA.
Blanca I RestrepoSchool of Public Health, University of Texas Health Science Center at Houston, Brownsville Campus, Brownsville, TX, 78520, USA. Blanca.i.restrepo@uth.tmc.edu.
Texas Biomedical Research Institute · USThe University of Texas Rio Grande Valley · USThe University of Texas Health Science Center at Houston · USSecretaria de Salud · MX

Funding

Social stress as a co-morbidity of age-associated tuberculosisP01AG051428 · NIA · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI TORRELLES, JORDI B · 2016 to 2020
$9.9M
NIA NIH HHS P01 AG051428NIA NIH HHS P01-AG051428
6 · The paper itself

Abstract

backgroundThe coronavirus disease 2019 pandemic is predicted to have a net negative effect on tuberculosis control, with an estimated excess of 6.3 million tuberculosis cases and 1.4 million deaths by 2025. Programmatic issues such as the lockdown of tuberculosis services affect all patients, while biosocial factors have a differential impact on an individual's risk for tuberculosis or adverse tuberculosis outcomes. CASE PRESENTATION: We report three Hispanic cases of incident tuberculosis (two males, 43 and 44 years old; one female, 49 years old) after resolution of coronavirus disease episodes. Coincidentally, all cases shared a common risk factor: a chronic history poorly controlled diabetes.

conclusionsOur findings alert to the threat posed by the synergy between coronavirus disease and diabetes, on tuberculosis reactivation. In medium- to high-risk settings for tuberculosis, we recommend implementation of routine screening for latent tuberculosis infection in these cases, and preventive tuberculosis treatment in those who are positive.

Indexed as

COVID-19Diabetes MellitusTuberculosisAdultCommunicable Disease ControlFemaleHumansMaleMiddle AgedSARS-CoV-2COVID-19Diabetes mellitusDiagnostic delaysSARS-CoV-2TuberculosisType 2 diabetes

Identifiers

PMID34915933
PMCPMC8674832
OpenAlexW4200380739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.