ArticleCritical care (London, England)2021
17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic shock: a randomized control trial.
Article in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Estrogen as a therapeutic agent: Targeting endotheliopathy and coagulopathy in trauma.Transfusion · 2026Review
- From molecular networks to precision therapeutics: the evolving landscape of trauma-induced coagulopathy.World journal of emergency surgery : WJES · 2026Review
- Oestradiol dynamics after polytrauma are linked to injury severity and adverse outcomes.Frontiers in endocrinology · 2026Article
- Results of therapy in children diagnosed with severe traumatic brain injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Gender Disparities in Trauma Patients With an Elevated Shock Index at a Rural Appalachian Trauma Center.Cureus · 2025Article
- Mitochondrial-targeted therapies in traumatic brain injury: From bench to bedside.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Facing stress and inflammation: From the cell to the planet.World journal of experimental medicine · 2024Review
- Induced blood flow oscillations at 0.1 Hz protects oxygenation of severely ischemic tissue in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Effects of remote ischemic preconditioning on early markers of intestinal injury in experimental hemorrhage in rats.Scientific reports · 2024Article
- Patient sex and outcomes in children with life-threatening hemorrhage.Transfusion · 2024Observational
- Sex dimorphisms in coagulation: Implications in trauma-induced coagulopathy and trauma resuscitation.American journal of hematology · 2024Review
- Transforming research to improve therapies for trauma in the twenty-first century.Critical care (London, England) · 2024Review
- Article
- Head Kinematics, Blood Biomarkers, and Histology in Large Animal Models of Traumatic Brain Injury and Hemorrhagic Shock.Journal of neurotrauma · 2023Article
- KDM4A, involved in the inflammatory and oxidative stress caused by traumatic brain injury-hemorrhagic shock, partly through the regulation of the microglia M1 polarization.BMC neuroscience · 2023Article
- Fresh Frozen Plasma Increases Hemorrhage in Blunt Traumatic Brain Injury and Uncontrolled Hemorrhagic Shock.Rambam Maimonides medical journal · 2023Article
- Polynitroxylated PEGylated hemoglobin protects pig brain neocortical gray and white matter after traumatic brain injury and hemorrhagic shock.Frontiers in medical technology · 2023Article
- The effect of extended continuous nursing strategy applied to patients with mild brain injury on their quality of life and self-efficacy.Frontiers in surgery · 2022Article
- Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis.Frontiers in immunology · 2022Review
- Predictive role of shock index in the early formation of cerebral infarction in patients with TBI and cerebral herniation.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundTraumatic brain injury (TBI) and severe blood loss resulting in hemorrhagic shock (HS) represent leading causes of trauma-induced mortality, especially when co-occurring in pre-hospital settings where standard therapies are not readily available. The primary objective of this study was to determine if 17α-ethinyl estradiol-3-sulfate (EE-3-SO
methodsAll methods were approved by required regulatory agencies prior to study initiation. In this fully randomized, blinded preclinical study, eighty (50% females) sexually mature (190.64 ± 21.04 days old; 28.18 ± 2.72 kg) Yucatan swine were used. Sixty-eight animals received a closed-head, accelerative TBI followed by removal of approximately 40% of circulating blood volume. Animals were then intravenously administered EE-3-SO
resultsA comparison of Placebo-treated relative to Sham animals indicated evidence of acidosis, decreased arterial pressure, increased heart rate, diffuse axonal injury and blood-brain barrier breach. The percentage of animals surviving to 295 min post-injury was significantly higher for the EE-3-SO
conclusionsEE-3-SO
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.