ArticleParticle and fibre toxicology2021
Chemistry, lung toxicity and mutagenicity of burn pit smoke-related particulate matter.
Article in Particle and fibre toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 66 citations in OpenAlex.
- Transcriptomic signature comparisons identify conserved key events and respiratory disease signatures most similar to wildfire-relevant exposure.Chemico-biological interactions · 2026Article
- Exposures to combustion sources near military operations in Iraq and Afghanistan using satellite observations.Journal of exposure science & environmental epidemiology · 2026Article
- Medical problems in military personnel associated with burn pit exposure: a narrative review.Journal of thoracic disease · 2026Review
- Interpretable Machine Learning to Understand Wildfire Toxicity: Bridging Chemicals, Omics, and Toxicological Outcomes via Symbolic Regression with Novel Feature Scoring.Chemical research in toxicology · 2026Article
- Current Issues Related to Combustion Byproducts & Human Health: A Summary of the 18th International PIC Congress.Environment & health (Washington, D.C.) · 2026Review
- Laboratory Analysis of VOC Emissions from Structural Materials in Wildland-Urban Interface Fires.Environmental science & technology · 2026Article
- Wildfires and Atopic Diseases: A Review.Allergy · 2026Review
- Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization.Cancer discovery · 2026Article
- Wood smoke particles elicit events associated with adverse effects in human lung epithelial cells.Frontiers in toxicology · 2026Article
- Ferroptosis in smoke inhalation injury: from mechanisms to potential therapeutic targets.Frontiers in cell and developmental biology · 2026Review
- Burn Pit Smoke Exposure and Sleep Apnea in US Veterans: A Retrospective Cohort Study.Medical care · 2026Article
- Quantitative lung particulate analysis links increased anthracotic pigment burden to burn pit exposure in post-9/11 veterans with distal lung disease.Scientific reports · 2025Article
- Identification and Quantitation ofMethods and protocols · 2025Article
- Seasonal PMParticle and fibre toxicology · 2025Article
- Chemical components of electric vehicle and internal combustion engine vehicle fire smoke and their mutagenic effects.Environmental science and pollution research international · 2025Article
- Combustion products of burn pit constituents induce more changes in asthmatic than non-asthmatic murine lungs.Particle and fibre toxicology · 2025Article
- RNA Sequencing Reveals Inflammatory and Metabolic Changes in the Lung and Brain After Carbon Black and Naphthalene Whole Body Inhalation Exposure in a Rodent Model of Military Burn Pit Exposures.International journal of molecular sciences · 2025Article
- Left ventricular concentric remodeling is highly common among veterans deployed to Southwest Asia and is associated with impaired exercise performance.Physiological reports · 2025Article
- Respiratory Health Impacts from Natural Disasters and Other Extreme Weather Events: The Role of Environmental Stressors on Asthma and Allergies.Current allergy and asthma reports · 2025Review
- Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundOpen burning of anthropogenic sources can release hazardous emissions and has been associated with increased prevalence of cardiopulmonary health outcomes. Exposure to smoke emitted from burn pits in military bases has been linked with respiratory illness among military and civilian personnel returning from war zones. Although the composition of the materials being burned is well studied, the resulting chemistry and potential toxicity of the emissions are not.
methodsSmoke emission condensates from either flaming or smoldering combustion of five different types of burn pit-related waste: cardboard; plywood; plastic; mixture; and mixture/diesel, were obtained from a laboratory-scale furnace coupled to a multistage cryotrap system. The primary emissions and smoke condensates were analyzed for a standardized suite of chemical species, and the condensates were studied for pulmonary toxicity in female CD-1 mice and mutagenic activity in Salmonella (Ames) mutagenicity assay using the frameshift strain TA98 and the base-substitution strain TA100 with and without metabolic activation (S9 from rat liver).
resultsMost of the particles in the smoke emitted from flaming and smoldering combustion were less than 2.5 µm in diameter. Burning of plastic containing wastes (plastic, mixture, or mixture/diesel) emitted larger amounts of particulate matter (PM) compared to other types of waste. On an equal mass basis, the smoke PM from flaming combustion of plastic containing wastes caused more inflammation and lung injury and was more mutagenic than other samples, and the biological responses were associated with elevated polycyclic aromatic hydrocarbon levels.
conclusionsThis study suggests that adverse health effects of burn pit smoke exposure vary depending on waste type and combustion temperature; however, burning plastic at high temperature was the most significant contributor to the toxicity outcomes. These findings will provide a better understanding of the complex chemical and combustion temperature factors that determine toxicity of burn pit smoke and its potential health risks at military bases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.