ArticleBMC pediatrics2021
A promising new predictive factor for detecting bowel resection in childhood intussusception: the lymphocyte-C-reactive protein ratio.
Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 16 citations in OpenAlex.
- Biomarker-Based Prediction of Treatment Outcomes in Pediatric Intussusception: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- A retrospective analysis of risk factors for intestinal necrosis in pediatric secondary intussusception.BMC pediatrics · 2026Article
- Predictive and Prognostic Biomarkers in Pediatric Intussusception-A Systematic Review.Journal of clinical medicine · 2026Review
- Adult Colonic Intussusception: A Focused Review of Diagnostic and Management Strategies.Medicina (Kaunas, Lithuania) · 2026Review
- Article
- Lymphocyte-C-reactive protein ratio upon admission to predict disease progression and ICU admission in adult patients with diabetic ketoacidosis.Scientific reports · 2025Article
- Hematological Markers to Predict Enterectomy Versus Enterotomy in Dogs with Foreign-Body Intestinal Obstruction: Preliminary Data.Animals : an open access journal from MDPI · 2024Article
- Predictive Factors for Bowel Resection in Childhood Intussusception.African journal of paediatric surgery : AJPS · 2024Article
- Rotavirus vaccination is a protective factor for adverse outcomes in primary intussusception: a single-center retrospective study.Translational pediatrics · 2024Article
- Dynamic lymphocyte-CRP ratio as a predictor: a single-centre retrospective study on disease severity and progression in adult COVID-19 patients.The Journal of international medical research · 2024Article
- Developing a Nomogram for Predicting Surgical Intervention in Pediatric Intussusception After Pneumatic Reduction: A Multicenter Study from China.Therapeutics and clinical risk management · 2024Article
- Developing and validating a nomogram for early predicting the need for intestinal resection in pediatric intussusception.Frontiers in pediatrics · 2024Article
- Developing a nomogram for predicting surgical intervention in pediatric intussusception after hydrostatic reduction.Frontiers in pediatrics · 2023Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe most critical concern for the management of childhood intussusception is bowel resection due to intestinal ischemia and necrosis. The early prediction of this problem is of great importance. We investigated the value of various combinations of inflammatory factors to predict intestinal necrosis and resection.
methodsWe retrospectively reviewed the medical records of pediatric patients with intussusception who underwent surgical management. During the research period, 47 patients who underwent intestinal resection due to intestinal necrosis and 68 patients who did not undergo intestinal resection were enrolled. We evaluated the diagnostic value of various combinations of inflammatory markers from preoperative laboratory analyses using the receiver operating characteristic (ROC) method.
resultsIn the current cohort, 115 patients underwent operations for intussusception; among them, 47 patients (40.9%) underwent intestinal resections. In the patients with intestinal resection, the neutrophil count(p = 0.013), CRP level(p = 0.002), platelet-lymphocyte ratio (PLR, p = 0.008), NLR (neutrophil-lymphocyte ratio, p = 0.026), and LCR (lymphocyte-CRP ratio, p < 0.001) values were significantly higher than those in the patients without any resection. The receiver operating characteristic (ROC) analysis results showed that the combination of lymphocytic count along with C-reactive protein levels (LCR) demonstrated the highest correlation with intestinal resection due to intussusception compared with other parameters in the patients, with a sensitivity of 0.82 (0.73-0.86) and specificity of 0.80 (0.57-0.94) for the diagnosis of strangulation.
conclusionThe preoperative LCR level is a useful marker to predict the need for intestinal resection due to intestinal necrosis in patients with intussusception.
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