Evidence map›Paper›PMID 34915839›Full record

Trial reportBMC cardiovascular disorders2021

Long-term hospital-based secondary prevention of coronary artery disease: a randomized controlled trial.

Anete Kaldal, Serena Tonstad, Jarle Jortveit

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00679237. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00679237 nacompleted

Risk Reduction in Coronary Heart Disease - a Prospective Randomized Study

Ran2007Enrolled1,600Registered outcomes1Posted comparisons0ConditionsCoronary Heart DiseaseArmsbetablocker, diuretics, ACEI, ARB,, influenza vaccine, metformin, glimepiride, insulin, smoking cessation, statins, ezetimibe
Open the trial in the graph
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Anete KaldalDepartment of Research, Sørlandet Hospital HF, Lundsiden, Box 416, 4604, Kristiansand S, Norway. anete.kaldal@gmail.com.
Serena TonstadDepartment of Endocrinology, Obesity and Preventive Medicine, Section of Preventive Cardiology, Oslo University Hospital, Oslo, Norway.
Jarle JortveitDepartment of Cardiology, Sørlandet Hospital Arendal, Arendal, Norway.
Oslo University Hospital · NOSørlandet Hospital Arendal · NOSørlandet Sykehus · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsDespite established guidelines on secondary prevention of cardiovascular disease, practical implementation of treatment targets is deficient even in high-income countries. This study compared long-term hospital-based treatment with follow-up at primary health care regarding new cardiovascular events and achievement of treatment targets.

methodsThis randomized controlled trial at Sørlandet Hospital, Norway 2007-2021 included patients hospitalized due to myocardial infarction (n = 760) or after scheduled percutaneous coronary intervention (PCI) (n = 677) or coronary artery bypass grafting (n = 103). Patients were randomized to hospital-based secondary preventive care with consultations 2 weeks, 3 months, 6 months and 1 year after the index event and annually for up to 5 years, or follow-up at primary health care. Final data was collected after 10 years and hazard ratios were calculated using Cox regression analyses.

resultsComposite endpoint-free survival due to a lower rate of PCI improved in patients with hospital-based follow-up (n = 788) compared to patients followed-up at primary health care (n = 752) (HR 0.80, 95% CI 0.66-0.96; p = 0.02) but all-cause mortality was not reduced (HR 0.96, 95% CI 0.59-1.56; p = 0.86). At 1 year, LDL-cholesterol (2.1 [SD 0.7] versus 2.3 [SD 0.8] mmol/l; p < 0.001) and systolic blood pressure (132 [SD 16] versus 142 [SD 20] mm/Hg; p < 0.001) were lower in the hospital-based group, and the differences remained significant during the first 5 years. Other secondary preventive measures (smoking cessation, physical activity, body weight, glucose control, drug adherence) did not differ.

conclusionsLong-term hospital-based secondary preventive follow-up improved composite endpoint-free survival, but not mortality. Substantial risk factors remained unaddressed. The beneficial effects on blood pressure and LDL-cholesterol disappeared after annual consultations ceased.

trial registrationThe study is registered in ClinicalTrials.gov (NCT00679237) May 16, 2008.

Indexed as

Cardiology Service, HospitalCoronary Artery BypassPercutaneous Coronary InterventionSecondary PreventionAgedCoronary Artery DiseaseFemaleHeart Disease Risk FactorsHumansMaleMiddle AgedNorwayPrimary Health CareRecurrenceReferral and ConsultationRisk AssessmentCardiovascular diseasesMyocardial infarctionSecondary prevention

Identifiers

PMID34915839
PMCPMC8679993
OpenAlexW4200033576

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.