Evidence map›Paper›PMID 34915729›Full record

ArticleCirculation. Cardiovascular imaging2021

Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis.

Ian Y Chen, Vijay Vedula, Sachin B Malik, Tie Liang, Andrew Y Chang, Kieran S Chung, Nazish Sayed, Philip S Tsao, John C Giacomini, Alison L Marsden and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Ian Y Chen *Stanford Cardiovascular Institute (I.Y.C., N.S., J.C.W.), Stanford University School of Medicine, CA.ORCID 0000-0002-9694-5468
Vijay Vedula *Department of Mechanical Engineering, Columbia University, New York, NY (V.V.).
Sachin B MalikDepartment of Radiology (S.B.M., T.L.), Stanford University School of Medicine, CA.
Tie LiangStanford Cardiovascular Institute (I.Y.C., N.S., J.C.W.), Stanford University School of Medicine, CA.
Andrew Y ChangDepartment of Medicine, Division of Cardiovascular Medicine (A.Y.C., P.S.T., J.C.G., J.C.W.), Stanford University School of Medicine, CA.ORCID 0000-0002-3009-6678
Kieran S ChungMedical Service, Cardiology Section (I.Y.C., K.S.C., J.C.G.), Veterans Affairs Palo Alto Health Care System, CA.
Nazish SayedStanford Cardiovascular Institute (I.Y.C., N.S., J.C.W.), Stanford University School of Medicine, CA.ORCID 0000-0002-8229-721X
Philip S TsaoDepartment of Medicine, Division of Cardiovascular Medicine (A.Y.C., P.S.T., J.C.G., J.C.W.), Stanford University School of Medicine, CA.ORCID 0000-0001-7274-9318
John C GiacominiDepartment of Medicine, Division of Cardiovascular Medicine (A.Y.C., P.S.T., J.C.G., J.C.W.), Stanford University School of Medicine, CA.
Alison L MarsdenDepartment of Bioengineering, Stanford University, Stanford, CA (A.L.M.).
Joseph C WuStanford Cardiovascular Institute (I.Y.C., N.S., J.C.W.), Stanford University School of Medicine, CA.ORCID 0000-0002-6068-8041
VA Palo Alto Health Care System · USCardiovascular Institute of the South · USStanford University · USViking Development Group (Norway) · NO

Funding

Multi-Disciplinary Training Program in Cardiovascular Imaging at StanfordT32EB009035 · NIBIB · STANFORD UNIVERSITY · PI Koen Nieman, John M. Pauly · 2008 to 2026
$4.3M
Molecular Imaging of Cardiac Pluripotent Stem CellsR01HL133272 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2016 to 2020
$2.4M
American Heart Association-American Stroke Association 18CDA34110047NHLBI NIH HHS R01 HL133272NIBIB NIH HHS T32 EB009035
6 · The paper itself

Abstract

backgroundComputed tomography-based evaluation of aortic stenosis (AS) by calcium scoring does not consider interleaflet differences in leaflet characteristics. Here, we sought to examine the functional implications of these differences.

methodsWe retrospectively reviewed the computed tomography angiograms of 200 male patients with degenerative calcific AS undergoing transcatheter aortic valve replacement and 20 male patients with normal aortic valves. We compared the computed tomography angiography (CTA)-derived aortic valve leaflet calcification load (AVLC

resultsIn patients with AS, the noncoronary cusp (NCC) carried the greatest AVLC

conclusionsIn male patients, the AVLC

Indexed as

AgedAged, 80 and overAortic ValveAortic Valve StenosisCalcinosisComputed Tomography AngiographyCross-Sectional StudiesHumansMaleMiddle AgedPreoperative CareRetrospective Studiesaortic valve stenosiscalciumcomputed tomography angiographycomputer simulationtranscatheter aortic valve replacement

Identifiers

PMID34915729
PMCPMC9206593
OpenAlexW4200091494

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.