ArticleMedeniyet medical journal2021
Evaluation of N/LP Ratio as a Predictor of Disease Progression and Mortality in COVID-19 Patients Admitted to the Intensive Care Unit.
Article in Medeniyet medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- The predictive value of the systemic immune-inflammation index in chronic thromboembolic pulmonary hypertension.Medicine · 2026Article
- Elevated blood viscosity is associated with dysautonomia in long COVID symptoms.American heart journal plus : cardiology research and practice · 2026Article
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- Researching impaired heart rate recovery index in patients who have had COVID-19.Northern clinics of Istanbul · 2026Article
- C-reactive protein-to-prealbumin ratio as prognostic marker in hemodialysis patients with Omicron infection.Renal failure · 2025Article
- Systemic inflammation response index (SIRI)-based risk of pneumonia following successful PCI in STEMI patients.Annals of medicine · 2025Article
- Correlation between the neutrophil-to-lymphocyte ratio and the 90-day all-cause mortality in patients with acute respiratory failure: a retrospective analysis based on the MIMIC-IV Database.BMC cardiovascular disorders · 2025Article
- Outcomes of Patients with Heart Failure Hospitalized for COVID-19-A Study in a Tertiary Italian Center.Diseases (Basel, Switzerland) · 2024Article
- Clinical utility of ambulatory ECG monitoring and 2D-ventricular strain for evaluation of post-COVID-19 ventricular arrhythmia.BMC cardiovascular disorders · 2024Observational
- Assessment of COVID-19 risk factors of early and long-term mortality with prediction models of clinical and laboratory variables.BMC infectious diseases · 2024Article
- Clinical predictive value of the initial neutrophils to lymphocytes and platelets ratio for prognosis of sepsis patients in the intensive care unit: a retrospective study.Frontiers in medicine · 2024Article
- Review
- Predictive value of neutrophil-to-lymphocyte and platelet ratio in in-hospital mortality in septic patients.Heliyon · 2022Article
- Article
- Estimation of Serum Ferritin in Mucormycosis Patients and Prognostication Based on the Ferritin Value.Cureus · 2022Article
- A Nomogram for Predicting In-Stent Restenosis Risk in Patients Undergoing Percutaneous Coronary Intervention: A Population-Based Analysis.International journal of general medicine · 2022Article
- Influence of the Initial Neutrophils to Lymphocytes and Platelets Ratio on the Incidence and Severity of Sepsis-Associated Acute Kidney Injury: A Double Robust Estimation Based on a Large Public Database.Frontiers in immunology · 2022Article
- A novel predictor of short-term prognosis in acute pulmonary embolism: inflammatory burden index.Therapeutic advances in cardiovascular diseaseArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This research aimed to evaluate whether the neutrophil to lymphocyte and platelet (N/LP) ratio may be used to predict the risk of admission to the intensive care unit (ICU), the need for mechanical ventilation and in-hospital mortality in Coronavirus disease 2019 (COVID-19) cases. Methods: The study was conducted retrospectively on the data of 134 COVID-19 patients who were admitted to the ICU. The N/LP ratio was calculated as follows: neutrophil count x 100 / (lymphocyte count x platelet count). Each member of the research cohort was categorised into 1 of 2 groups based on their survival status (survivor and non-survivor groups). Results: In total, 82 (61%) patients died during the ICU stay. Patients who required mechanical ventilation and died in the ICU stay had significantly higher N/LP ratio than those who did not require it and survived [10 (IQR=4.94-19.38) vs 2.51 (IQR=1.67-5.49), p<0.001] and [11.27 (IQR=4.53-30.02) vs 1.65 (IQR=1-3.24), p<0.001], respectively. The N/LP ratio was linked with the requirement of mechanical ventilation and in-hospital death according to multivariable analysis. In receiver operating characteristic curve analysis, we found that N/LP in predicting admission to the ICU was >4.18 with 61% sensitivity and 62% specificity, it was >5.07 with 74% sensitivity and 73% specificity for the need for mechanical ventilation, and >3.69 with 81% sensitivity and 81% specificity to predict in-hospital death. Conclusion: To our knowledge, this is the first study showing that the N/LP ratio, which is a novel and widely applicable inflammatory index, may be used to predict the risk of ICU admission, mechanical ventilation and in-hospital death in patients with COVID-19 disease.
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