ArticleAesthetic surgery journal2022
Impact of Capsulectomy Type on Post-Explantation Systemic Symptom Improvement: Findings From the ASERF Systemic Symptoms in Women-Biospecimen Analysis Study: Part 1.
Article in Aesthetic surgery journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Breast Implant Illness: Symptoms, Outcomes with Explantation and Potential Etiologies-A Systematic Review and Meta-analysis.Aesthetic plastic surgery · 2025Pooled it
- Heavy Metals in Breast Implants and Implications for Breast Implant Illness: A Systematic Review of the Literature.Aesthetic plastic surgery · 2025Pooled it
- From Bench to Bedside: Clinical Implications of a 4-Micron Surface-Modulated Immune Response in the Era of Breast Tissue Preservation.Aesthetic surgery journal · 2026Review
- Revision Mastopexy in Aesthetic Breast Surgery.Aesthetic plastic surgery · 2026Review
- Management of Asymptomatic Breast Implant Rupture in Older Adult Patients: A Scoping Review, Discussion, and Recommendations.Plastic and reconstructive surgery. Global open · 2026Article
- Systematic biocompatibility assessment of 4-µm surface silicone implants.Biomaterials and biosystems · 2026Article
- Concerns with the Manuscript: Breast Implant Illness: Symptoms, Outcomes with Explantation and Potential Etiologies-A Systemic Review and Meta-analysis.Aesthetic plastic surgery · 2026Article
- Clinical Outcomes in Women with Breast Implant Illness After Removal Surgery: Experience from a Latin American Center.Aesthetic plastic surgery · 2026Observational
- From Hashtags to Health Narratives: A Content Analysis of Breast Implant Illness on TikTok.Aesthetic plastic surgery · 2025Article
- The Occurrence of Health Symptoms in General Practice Before and After the Explantation of Cosmetic Breast Implants.Aesthetic surgery journal · 2025Article
- The Diagnosis and Management of Patients With Findings Consistent With a Breast Implant Associated-Somatic Symptom Disorder (BIA-SSD).Plastic and reconstructive surgery. Global open · 2025Article
- Defining Breast Implant Illness: A Systematic Review and Meta-analysis of Patient-reported Symptoms.Plastic and reconstructive surgery. Global open · 2025Article
- Breast Implant Removal-Only: The Role of Targeted Compression.Aesthetic plastic surgery · 2025Article
- Recognizing and Managing Breast Implant Complications: A Review for Healthcare Providers Who Treat Women Who Underwent Breast Implant-Based Surgery.International journal of women's health · 2025Review
- Medical Specialist Care Utilization Prior to the Explantation of Cosmetic Silicone Breast Implants: A Nationwide Retrospective Data Linkage Study.Aesthetic plastic surgery · 2024Article
- Findings Consistent with a Breast Implant-associated Somatic System Disorder (BIA-SSD) Among Patients Self-reporting Breast Implant Illness.Plastic and reconstructive surgery. Global open · 2024Article
- Oxylipins in Breast Implant-Associated Systemic Symptoms.Aesthetic surgery journal · 2024Article
- Correlation Between Medically Diagnosed Anxiety and Depression Disorder and Self-Reported Breast Implant Illness.Aesthetic surgery journal · 2024Article
- Clinical Evaluation of Microbial Communities and Associated Biofilms with Breast Augmentation Failure.Microorganisms · 2024Article
- Complications of Aesthetic and Reconstructive Breast Implant Capsulectomy: An Analysis of 7486 Patients Using Nationwide Outcomes Data.Aesthetic surgery journal · 2024Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast Implant Illness (BII) is a term used to describe a variety of symptoms by patients with breast implants for which there are no abnormal physical or laboratory findings to explain their symptoms. There currently exists a difference of opinion among clinicians and patients concerning the diagnosis and treatment of patients self-reporting BII.
objectivesThe first aim of this study was to determine if there is a valid indication for "en bloc" capsulectomy in patients self-reporting BII and if the type of capsulectomy performed alters long-term symptom improvement. The second goal was to identify any clinical laboratory differences between the cohorts. This study was funded by the Aesthetic Surgery Education and Research Foundation (ASERF).
methodsA prospective blinded study enrolled 150 consecutive subjects divided equally into 3 cohorts: (A) women with systemic symptoms they attribute to their implants who requested implant removal; (B) women with breast implants requesting removal or exchange who do not have symptoms they attribute to their implants; and (C) women undergoing cosmetic mastopexy who have never had any implanted medical device. The subject's baseline demographic data and a systemic symptoms survey, including PROMIS validated questionnaires, was obtained before surgery and at 3-6 weeks, 6 months, and 1 year. Blood was collected from all 3 cohorts and implant capsules were collected from Cohorts A and B.
results150 patients were enrolled between 2019-2021. Follow-up at 3-6 weeks for all 3 cohorts was between 98%-100%, 78%-98% at 6-months, and 1 year data is currently at 80%. The type of capsulectomy; intact total, total, or partial all showed similar symptom improvement with no statistical difference in the reduction of symptoms based on the type of capsulectomy.
conclusionsThis study addresses one of the most discussed questions by plastic surgeons, patients, their advocates, and social media. The findings show that patients who self-report BII demonstrate a statistically significant improvement in their symptoms after explantation and that this improvement persists for at least 6 months. This improvement in self-reported systemic symptoms was seen regardless of the type of capsulectomy performed. LEVEL OF EVIDENCE: 2:
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