Evidence map›Paper›PMID 34915517›Full record

ReviewOphthalmic research2022

Gut Microbes and Eye Disease.

Patrick Donabedian, Elizabeth Dawson, Qiuhong Li, Jinghua Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ophthalmic research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Targeting the Gut-Eye Axis: An Emerging Strategy to Face Ocular Diseases.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Patrick DonabedianCollege of Medicine, University of Florida, Gainesville, Florida, USA, donabedian@ufl.edu.
Elizabeth DawsonCollege of Medicine, University of Florida, Gainesville, Florida, USA.
Qiuhong LiDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA.
Jinghua ChenDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA.

Funding

Oral therapy for diabetic retinopathy using ACE2/Ang1-7 bioencapsulated in plant cellsR01EY024564 · NEI · UNIVERSITY OF FLORIDA · PI DANIELL, HENRY, LI, QIUHONG · 2015 to 2018
$1.6M
ACE2 Modulates the Bone Marrow- Gut Axis in Diabetic RetinopathyR01EY028858 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, GRANT, MARIA BARTOLOMEO · 2018 to 2021
$1.6M
Ocular Renin Angiotensin System in Pathogenesis of Diabetic RetinopathyR01EY021752 · NEI · UNIVERSITY OF FLORIDA · PI LI, QIUHONG · 2012 to 2015
$1.4M
NEI NIH HHS R01 EY021752NEI NIH HHS R01 EY024564NEI NIH HHS R01 EY028858
6 · The paper itself

Abstract

Microbial symbionts in the gut are increasingly recognized as having important effects on health and disease, but have only recently begun to be linked to diseases of the eye. We review current research on the intestinal microbiota's relationship to ocular disease, focusing on autoimmune uveitis, diabetic retinopathy, age-related macular degeneration, and primary-open angle glaucoma. We discuss findings and limitations of this exciting new area of ophthalmology research and explore possible future disease-modifying treatments.

Indexed as

Diabetic RetinopathyEye DiseasesGastrointestinal MicrobiomeGlaucomaGlaucoma, Open-AngleUveitisEyeHumansAge-related macular degenerationAutoimmune uveitisDiabetic retinopathyGlaucomaGut microbiome

Identifiers

PMID34915517
PMCPMC9198007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.