Evidence map›Paper›PMID 34915426›Full record

ArticleThe International journal on drug policy2022

Methadone within prison and linkage to and retention in treatment upon community release for people with opioid use disorder in Kyrgyzstan: Evaluation of a national program.

Chethan Bachireddy, Roman Shrestha, Daniel J Bromberg, Lyu Azbel, Ainura Kurmanalieva, Martin Wegman, Natalya Shumskaya, Julia Rozanova, Jaimie P Meyer, Frederick L Altice

Open access · greenAbstract read
In one paragraph

Article in The International journal on drug policy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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  7. Pilot of Methadone for Recently Incarcerated People with Human Immunodeficiency Virus and Opioid Use in South Africa.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chethan BachireddyVirginia Commonwealth University School of Medicine, Richmond, VA, United States; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PS, United States.
Roman ShresthaDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, United States; Yale University School of Medicine, New Haven, CT, United States.
Daniel J BrombergYale University School of Public Health, New Haven, CT, United States; Center for Interdisciplinary Research on AIDS, Yale University, New Haven, CT, United States.
Lyu AzbelYale University School of Medicine, New Haven, CT, United States.
Ainura KurmanalievaAFEW Kyrgyzstan, Research Department, Bishkek, Kyrgyzstan.
Martin WegmanUniversity of North Carolina School of Medicine, Chapel Hill, NC, United States.
Natalya ShumskayaCenter for Interdisciplinary Research on AIDS, Yale University, New Haven, CT, United States.
Julia RozanovaYale University School of Medicine, New Haven, CT, United States.
Jaimie P MeyerYale University School of Medicine, New Haven, CT, United States.
Frederick L AlticeYale University School of Medicine, New Haven, CT, United States; Yale University School of Public Health, New Haven, CT, United States; Center for Interdisciplinary Research on AIDS, Yale University, New Haven, CT, United States. Electronic address: Frederick.Altice@yale.edu.
Yale University · USUniversity of North Carolina at Chapel Hill · USUniversity of Pennsylvania · US

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
INTERDISCIPLINARY HIV PREVENTION TRAINING PROGRAMT32MH020031 · NIMH · YALE UNIVERSITY · PI Trace S Kershaw · 1999 to 2026
$12.1M
Prison Interventions and HIV Prevention CollaborationR01DA029910 · NIDA · YALE UNIVERSITY · PI FREDERICK LEWIS ALTICE · 2010 to 2026
$7.9M
Global Health Fellows and Scholars Research TrainingR25TW009338 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARRY, MICHELE, KO, ALBERT ICKSANG · 2012 to 2016
$5.2M
Training in MHealth Prevention with MSMK01DA051346 · NIDA · YALE UNIVERSITY · PI SHRESTHA, ROMAN · 2020 to 2024
$862k
Adapting a disclosure decision-aid to improve HIV outcomes for older adults in UkraineR34MH130260 · NIMH · YALE UNIVERSITY · PI ROZANOVA, JULIA · 2022 to 2024
$700k
Exploring the Feasibility of a Peer-Driven Intervention to Improve HIV Prevention among Prisoners Who Inject DrugsK01DA047194 · NIDA · YALE UNIVERSITY · PI ROZANOVA, JULIA · 2019 to 2023
$685k
Adapting Peer Navigation for Out-of-Care Older Persons with HIV in UkraineR21AG072961 · NIA · YALE UNIVERSITY · PI ROZANOVA, JULIA, SHENOI, SHEELA · 2021 to 2022
$604k
Modeling the impact and cost-effectiveness of opioid agonist treatments to reduce the negative consequences of incarceration on HIV and TB transmission in Eastern Europe and Central AsiaR21DA047902 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2020 to 2021
$378k
Prisons, Drug Injection and the HIV Risk EnvironmentR21DA042702 · NIDA · YALE UNIVERSITY · PI MEYER, JAIMIE · 2017 to 2018
$358k
Developing, Implementing, and Pilot Testing an Informed Decision Aid for Opioid Agonist Therapies for Prisoners in UkraineF31DA054861 · NIDA · YALE UNIVERSITY · PI BROMBERG, DANIEL J · 2021 to 2023
$94k
FIC NIH HHS D43 TW010540FIC NIH HHS R25 TW009338NIA NIH HHS R21 AG072961NIDA NIH HHS F31 DA054861NIDA NIH HHS K01 DA047194NIDA NIH HHS K01 DA051346NIDA NIH HHS R01 DA029910NIDA NIH HHS R21 DA042702NIDA NIH HHS R21 DA047902NIMH NIH HHS R34 MH130260NIMH NIH HHS T32 MH020031
6 · The paper itself

Abstract

backgroundHIV incidence in Eastern Europe and Central Asia (EECA) continues to increase, primarily among people who inject drugs (PWID) and people in prisons. In Kyrgyzstan, an estimated 35% of people in prison are PWID, and 10% have been diagnosed with HIV. In 2008, Kyrgyzstan became the first country in EECA to provide free and voluntary methadone in prisons. We examine the impact of this national program on methadone within prison as well as linkage to and retention in treatment upon release to the community.

methodsAdministrative data from a national methadone registry with de-identified information were assessed retrospectively. We examined the delivery of methadone services, including the duration of treatment both within prison and after release, for all prisoners who were prescribed methadone in Kyrgyz prisons from 2008 to 2018. Reasons for discontinuing methadone, HIV status and methadone dose are also analyzed.

resultsBetween 2008 and 2018, nine of Kyrgyzstan's 16 prisons offered methadone, and 982 incarcerated people initiated methadone within prison. Prisoners prescribed methadone were mostly male (96.2%), in their mid-30s (mean=34.9 years), and had been incarcerated for a relatively long time (mean = 44.1 months); their mean treatment duration in prison was 12.5 months, and 31.6% had HIV. A subsample (N = 645; 65.7%) of these were released to the community. Of these 645 people, 356 (55.2%) were not taking methadone at the time of release, 128 (19.8%) were on methadone and continued it after release, and the remainder (N=161, 25.0%) were on methadone at the time of release, but subsequently discontinued it, most within the first 7 days after release. Among those continuing methadone, 14.8% (N=19) remained on treatment ≥ 12 months. Independent correlates of linkage to methadone after release included positive HIV status (adjusted hazard ratio (aHR)=1.55; p = 0.033), receipt of methadone before their incarceration (aHR=2.01; p = 0.039), and receipt of methadone at the time of release (aHR = 20.81; p<0.001).

conclusionThis is the first evaluation of within-prison methadone treatment in EECA. Uptake of methadone within prison and retention in treatment after release were both low. Continuous maintenance of treatment throughout incarceration is an opportunity to optimize HIV prevention and link patients to methadone post-release.

Indexed as

HIV InfectionsOpioid-Related DisordersPrisonersSubstance Abuse, IntravenousFemaleHumansKyrgyzstanMaleMethadonePrisonsRetrospective StudiesMethadoneHIV/AIDSHIV preventionKyrgyzstanMethadoneOpioid agonist therapyPeople who inject drugsPrisons

Identifiers

PMID34915426
PMCPMC9998103
OpenAlexW4200172490

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.