ArticleInternational journal of hygiene and environmental health2022
Alterations of fecal antibiotic resistome in COVID-19 patients after empirical antibiotic exposure.
Article in International journal of hygiene and environmental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Review
- Broad-spectrum antibiotic treatment reshapes the gut microbiome, resistome, and colonization potential of opportunistic pathogens: a metagenomics study.Gut pathogens · 2026Article
- Gut microbiome resistotypes reflect chronological age andFrontiers in microbiology · 2026Article
- Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2025Review
- Development of a host-signature-based machine learning model to diagnose bacterial and viral infections in febrile children.Frontiers in pediatrics · 2025Article
- Molecular pathogen profiling of COVID-19 coinfections.BMC infectious diseases · 2024Article
- Prediction of tsunami of resistance to some antibiotics is not far-fetched which used during COVID-19 pandemic.Journal of clinical laboratory analysis · 2023Review
- Repeated antibiotic exposure and risk of hospitalisation and death following COVID-19 infection (OpenSAFELY): a matched case-control study.EClinicalMedicine · 2023Article
- Ecology and Machine Learning-Based Classification Models of Gut Microbiota and Inflammatory Markers May Evaluate the Effects of Probiotic Supplementation in Patients Recently Recovered from COVID-19.International journal of molecular sciences · 2023Article
- Article
- To Prescribe, or Not to Prescribe, That Is the Question.Journal of Korean medical science · 2022Article
- Empirical Antibiotic Prescribing in Adult COVID-19 Inpatients over Two Years in Mexico.Antibiotics (Basel, Switzerland) · 2022Article
- Application of Nanomaterials in the Prevention, Detection, and Treatment of Methicillin-ResistantPharmaceutics · 2022Review
- Antibiotic-Induced Primary Biles Inhibit SARS-CoV-2 Endoribonuclease Nsp15 Activity in Mouse Gut.Frontiers in cellular and infection microbiology · 2022Article
- The Relationship Between Pediatric Gut Microbiota and SARS-CoV-2 Infection.Frontiers in cellular and infection microbiology · 2022Article
- Article
- Antibiotics and probiotics impact gut antimicrobial resistance gene reservoir in COVID-19 patients.Gut microbesArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the COVID-19 pandemic spread globally, the consumption of antibiotics increased. However, no studies exist evaluating the effect of antibiotics use on the antibiotic resistance of intestinal flora in COVID-19 patients during the pandemic. To explore this issue, we collected 15 metagenomic data of fecal samples from healthy controls (HCs) with no use history of antibiotics, 23 metagenomic data of fecal samples from COVID-19 patients who received empirical antibiotics [COVID-19 (abx+)], 18 metagenomic data of fecal samples from antibiotics-naïve COVID-19 patients [COVID-19 (abx-)], and six metagenomic data of fecal samples from patients with community-acquired pneumonia [PC (abx+)] from the Sequence Read Archive database. A total of 513 antibiotic-resistant gene (ARG) subtypes of 18 ARG types were found. Antibiotic treatment resulted in a significant increase in the abundance of ARGs in intestinal flora of COVID-19 patients and markedly altered the composition of ARG profiles. Grouped comparisons of pairs of Bray-Curtis dissimilarity values demonstrated that the dissimilarity of the HC versus the COVID-19 (abx+) group was significantly higher than the dissimilarity of the HC versus the COVID-19 (abx-) group. The mexF, mexD, OXA_209, major facilitator superfamily transporter, and EmrB_QacA family major facilitator transporter genes were the discriminative ARG subtypes for the COVID-19 (abx+) group. IS621, qacEdelta, transposase, and ISCR were significantly increased in COVID-19 (abx+) group; they greatly contributed toward explaining variation in the relative abundance of ARG types. Overall, our data provide important insights into the effect of antibiotics use on the antibiotic resistance of COVID-19 patients during the COVID-19 epidemic.
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