Evidence map›Paper›PMID 34915270›Full record

ArticleDrug and alcohol dependence2022

Can social media monitoring help identify the next EVALI? An examination of Reddit posts about vitamin E acetate and Dank Vapes.

Jessica K Pepper, Lauren V Zitney, Alexander Preiss, Thomas Bukowski, Glen Szczypka, Annice E Kim

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Pharmacovigilance in the digital age: gaining insight from social media data.Experimental biology and medicine (Maywood, N.J.) · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jessica K PepperRTI International, 3040 E. Cornwallis Rd., Research Triangle Park, NC, USA. Electronic address: jpepper@rti.org.
Lauren V ZitneyRTI International, 3040 E. Cornwallis Rd., Research Triangle Park, NC, USA.
Alexander PreissRTI International, 3040 E. Cornwallis Rd., Research Triangle Park, NC, USA.
Thomas BukowskiRTI International, 3040 E. Cornwallis Rd., Research Triangle Park, NC, USA.
Glen SzczypkaRTI International, 3040 E. Cornwallis Rd., Research Triangle Park, NC, USA.
Annice E KimRTI International, 3040 E. Cornwallis Rd., Research Triangle Park, NC, USA.
RTI International · US

Funding

Co-Abuse Cannabis and TobaccoR33DA044377 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI MARUSICH, JULIE A · 2019 to 2021
$2.7M
NIDA NIH HHS R33 DA044377
6 · The paper itself

Abstract

backgroundScientists identified vitamin E acetate (VEA) and "Dank Vapes" (a fake brand of tetrahydrocannabinol [THC] vaping products) as contributors to the 2019-2020 outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI). On social media, people who post about vaping or THC discussed the causes of EVALI. We examined whether Reddit conversations may have served as early signals of the outbreak.

methodsWe collected Reddit posts from March 2018 to February 2020 on vaping- and THC-related subreddits that mentioned VEA or Dank Vapes. We identified peaks in post volume, examined post content, and used natural language processing to identify terms most characteristic of posts.

resultsThere were almost no posts about VEA before EVALI. Subsequently, there were two peaks, both referencing media coverage of scientific findings that linked VEA to EVALI. Discussion regularly referenced concerns about the legitimacy of Dank Vapes before EVALI; peaks in posts were largely unrelated to scientific findings or media coverage of those findings. The terms most characteristic of VEA posts were EVALI-related; those most characteristic of Dank Vapes posts were about quality or legitimacy.

conclusionsAlthough posts about VEA and Dank Vapes did not predict the outbreak, the public health community could use social media to encourage people who vape or use THC to report future health concerns (e.g., through FDA's Safety Reporting Portal). Researchers and regulators could also use social media to see if potentially problematic products, such as Dank Vapes, have a history of concern among individuals who use those products.

Indexed as

Electronic Nicotine Delivery SystemsSocial MediaVapingAcetatesHumansVitamin EAcetatesVitamin EDank VapesEVALISocial mediaTHCVapingVitamin E acetate

Identifiers

PMID34915270
PMCPMC8728682
OpenAlexW3216446263

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.