Evidence map›Paper›PMID 34914884›Full record

ArticleThe Journal of international medical research2021

Virucidal effect of povidone-iodine against SARS-CoV-2

Ying Wang, Yutong Wu, Qingjing Wang, Jiajie Zhu, Wen Shi, Zetao Han, Yanjun Zhang, Keda Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying WangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Centre for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Centre of Zhejiang University, Hangzhou, Zhejiang Province, China.
Yutong WuDepartment of Basic Medical Sciences, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang Province, China.
Qingjing WangDepartment of Basic Medical Sciences, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang Province, China.
Jiajie ZhuDepartment of Basic Medical Sciences, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang Province, China.
Wen ShiDepartment of Microbiology, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province, China.
Zetao HanDepartment of Basic Medical Sciences, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang Province, China.
Yanjun ZhangDepartment of Microbiology, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province, China.
Keda ChenDepartment of Basic Medical Sciences, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang Province, China.ORCID https://orcid.org/0000-0002-9469-0991

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the antiviral activity of the oral disinfectant povidone-iodine (PVP-I) against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV2)

methodsThe cytotoxic effects of PVP-I were determined in Vero and Calu-3 cell lines using that by Cell Counting Kit-8 assay. Viral load in the cell culture medium above infected cells was quantitated using real-time polymerase chain reaction. The cytopathic effect (CPE) and viral infective rate were observed by immunofluorescence microscopy.

resultsPVP-I at a concentration >0.5 mg/ml in contact with SARS-CoV-2 for 30 s, 1 min, 2 min and 5 min showed up to 99% viral inhibition. For

conclusionThese results demonstrate that the ideal contact time was 1 min and the optimal concentration was 1 mg/ml, which provides an experimental basis for the use of oral disinfectants in dental hospitals.

Indexed as

COVID-19SARS-CoV-2Cell LineHumansPovidone-IodineRNA, ViralPovidone-IodineRNA, Viralantiviral effectPovidone-iodineprophylaxispublic healthSARS-CoV-2

Identifiers

PMID34914884
PMCPMC8689632

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.