Evidence map›Paper›PMID 34914877›Full record

ArticleJournal of the American Chemical Society2021

Ligand Enabled Pd(II)-Catalyzed γ-C(sp

Shuang Liu, Zhe Zhuang, Jennifer X Qiao, Kap-Sun Yeung, Shun Su, Emily C Cherney, Zheming Ruan, William R Ewing, Michael A Poss, Jin-Quan Yu

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 47 citations in OpenAlex.

  1. From Mono-Accounts of chemical research · 2025
    Review
  2. Copper-Catalyzed γ-C(spAngewandte Chemie (International ed. in English) · 2025
    Article
  3. Article
  4. Ligand-Controlled NondirectedACS catalysis · 2024
    Article
  5. Palladium-catalysed methylene C(Nature synthesis · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. PdACS catalysis · 2022
    Article
  10. Ligand-Enabled β-C(spAngewandte Chemie (International ed. in English) · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shuang LiuDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0001-6341-8103
Zhe ZhuangDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0001-6679-0496
Jennifer X QiaoDiscovery Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Kap-Sun YeungBristol Myers Squibb Research and Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States.ORCID 0000-0003-3995-6555
Shun SuBristol Myers Squibb, 10300 Campus Point Drive Suite 100, San Diego, California 92121, United States.ORCID 0000-0001-8100-9645
Emily C CherneyDiscovery Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543, United States.ORCID 0000-0003-1977-2900
Zheming RuanDiscovery Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543, United States.ORCID 0000-0003-4485-4457
William R EwingDiscovery Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543, United States.ORCID 0000-0002-9434-8053
Michael A PossDiscovery Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Jin-Quan YuDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0003-3560-5774
Bristol-Myers Squibb (United States) · USScripps Research Institute · US

Funding

Ligand-promoted Enantioselective C-H Activation ReactionsR01GM084019 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI YU, JIN-QUAN · 2008 to 2024
$9.5M
NIGMS NIH HHS R01 GM084019
6 · The paper itself

Abstract

γ-Lactams form important structural cores of a range of medicinally relevant natural products and clinical drugs, principal examples being the new generation of immunomodulatory imide drugs (IMiDs) and the brivaracetam family. Compared to conventional multistep synthesis, an intramolecular γ-C-H amination of aliphatic amides would allow for the direct construction of valuable γ-lactam motifs from abundant amino acid precursors. Herein we report a novel 2-pyridone ligand enabled Pd(II)-catalyzed γ-C(sp

Indexed as

AmidesCatalysisLactamsMolecular StructurePalladiumAmidesLactamsPalladium

Identifiers

PMID34914877
PMCPMC9116424
OpenAlexW4200524316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.