ArticleScience immunology2022
High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells.
Abstract read
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Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Antibody Fc receptor binding and T cell responses to homologous and heterologous immunization with inactivated or mRNA vaccines against SARS-CoV-2.Nature communications · 2024Trial
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Germinal center-independent memory B cells provide rapid protection from lethal influenza challenges.bioRxiv : the preprint server for biology · 2026Article
- Extrafollicular and other non-germinal center B cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Article
- Extrafollicular and Other Non-Germinal Center B Cell Responses: An Evolutionary Perspective.Immunological reviews · 2025Review
- Tissue-Resident T Cells That Promote Humoral Immunity: Emerging From the Shadow of T Follicular Helper Cells.Immunological reviews · 2025Review
- Decrypting the Immune Symphony for RNA Vaccines.Vaccines · 2025Review
- T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses.The EMBO journal · 2025Article
- mRNA vaccine-induced SARS-CoV-2 spike-specific IFN-γ and IL-2 T-cell responses are predictive of serological neutralization and are transiently enhanced by pre-existing cross-reactive immunity.Journal of virology · 2025Article
- T cell-derived IFN-γ Suppresses T Follicular Helper Cell Differentiation and Antibody Responses.bioRxiv : the preprint server for biology · 2025Article
- Distinct Requirements for CD4European journal of immunology · 2025Article
- Article
- An Integrated Signaling Threshold Initiates IgG Response toward Virus-like Immunogens.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Development of T follicular helper cell-independent nanoparticle vaccines for SARS-CoV-2 or HIV-1 by targeting ICOSL.NPJ vaccines · 2024Article
- A novel microporous biomaterial vaccine platform for long-lasting antibody mediated immunity against viral infection.Journal of controlled release : official journal of the Controlled Release Society · 2024Article
- Investigating the impact of prior COVID-19 on IgG antibody and interferon γ responses after BBIBP-CorV vaccination in a disease endemic population: A prospective observational study.Health science reports · 2023Article
- Vaccine-elicited B- and T-cell immunity to SARS-CoV-2 is impaired in chronic lung disease patients.ERJ open research · 2023Article
- SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease.Nature medicine · 2023Article
- Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells.Science advances · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Jennifer S ChenDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7808-2670
Ryan D ChowDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1872-6307
Eric SongDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5448-5865
Tianyang MaoDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-9251-8592
Benjamin IsraelowDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1308-8246
Kathy KamathSerimmune Inc., Goleta, CA, USA.ORCID 0000-0001-6143-3414
Joel BozekowskiSerimmune Inc., Goleta, CA, USA.ORCID 0000-0002-1146-0016
Winston A HaynesSerimmune Inc., Goleta, CA, USA.ORCID 0000-0002-2376-0630
Renata B FillerDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8579-8418
Bridget L MenascheDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3520-2422
Jin WeiDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2832-1610
Mia Madel AlfajaroDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6402-2730
Wenzhi SongDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Lei PengDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Lauren CarterInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0002-9837-9068
Jason S WeinsteinCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, USA.ORCID 0000-0001-9918-2817
Uthaman GowthamanDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID 0000-0002-5484-7851
Sidi ChenDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3819-5005
Joe CraftDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1368-6756
John C ShonSerimmune Inc., Goleta, CA, USA.ORCID 0000-0001-9465-6286
Akiko IwasakiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7824-9856
Craig B WilenDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2495-9403
Stephanie C EisenbarthDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1244-208X
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MMedical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5MINTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4MIMMUNOHEMATOLOGY/TRANSFUSION MEDICINE RESEARCH TRAININGT32HL007974 · NHLBI · YALE UNIVERSITY · PI JEANNE E HENDRICKSON, Diane S Krause · 2001 to 2026
$8.1MIMMUNE RESPONSES IN LUPUSR37AR040072 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2000 to 2025
$7.4MTRAINING IN THE PATHOGENESIS OF INFECTIOUS DISEASEST32AI007517 · NIAID · YALE UNIVERSITY · PI Jaimie Meyer, Albert C Shaw · 1997 to 2026
$6.1MImmune Mechanisms Regulating AllergyR01AI136942 · NIAID · YALE UNIVERSITY · PI Stephanie Caroline Eisenbarth, ADAM WILLIAMS · 2018 to 2026
$5.1MThe role of tuft cells in norovirus pathogenesisR01AI148467 · NIAID · YALE UNIVERSITY · PI Craig Brian Wilen · 2020 to 2026
$3.9MFollicular Helper T Cell Function in AutoimmunityR01AR074545 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2019 to 2022
$1.3MRole of virus-receptor interactions in determining norovirus tropism and pathogenesis in vivoK08AI128043 · NIAID · YALE UNIVERSITY · PI WILEN, CRAIG BRIAN · 2017 to 2021
$940kMechanosensation in tumorigenesis and metastasisF30CA250249 · NCI · YALE UNIVERSITY · PI CHOW, RYAN D · 2020 to 2022
$113kRegulation of T cell-derived cytokines in allergic airway inflammationF30HL149151 · NHLBI · YALE UNIVERSITY · PI CHEN, JENNIFER S · 2020 to 2022
$113kNCATS NIH HHS UL1 TR001863NCI NIH HHS F30 CA239444NCI NIH HHS F30 CA250249NHLBI NIH HHS F30 HL149151NHLBI NIH HHS T32 HL007974NIAID NIH HHS K08 AI128043NIAID NIH HHS R01 AI136942NIAID NIH HHS R01 AI148467NIAID NIH HHS T32 AI007019NIAID NIH HHS T32 AI007517NIAMS NIH HHS R01 AR074545NIAMS NIH HHS R37 AR040072NIGMS NIH HHS T32 GM136651
Abstract
T follicular helper (T
Indexed as
Amino Acid SequenceAnimalsAntibodies, NeutralizingAntibodies, ViralAntibody FormationB-LymphocytesCOVID-19COVID-19 VaccinesGerminal CenterHumansLymphocyte ActivationMiceSARS-CoV-2T Follicular Helper CellsT-Lymphocytes, Helper-InducerAntibodies, NeutralizingAntibodies, ViralCOVID-19 Vaccines
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.