Evidence map›Paper›PMID 34914519›Full record

ArticleScience (New York, N.Y.)2021

Supramammillary regulation of locomotion and hippocampal activity.

Jordan S Farrell, Matthew Lovett-Barron, Peter M Klein, Fraser T Sparks, Tilo Gschwind, Anna L Ortiz, Biafra Ahanonu, Susanna Bradbury, Satoshi Terada, Mikko Oijala and 7 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jordan S FarrellDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1209-5559
Matthew Lovett-BarronDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1425-5277
Peter M KleinDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3232-3387
Fraser T SparksDepartment of Neuroscience, Columbia University, New York, NY, USA.ORCID 0000-0002-4716-5246
Tilo GschwindDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4261-218X
Anna L OrtizDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0002-7868-0080
Biafra AhanonuDepartments of Biology and Applied Physics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2021-5848
Susanna BradburyDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5509-8998
Satoshi TeradaDepartment of Neuroscience, Columbia University, New York, NY, USA.ORCID 0000-0002-4251-4304
Mikko OijalaDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Ernie HwaunDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0468-8346
Barna DudokDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5078-0090
Gergely SzaboDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4186-3211
Mark J SchnitzerDepartments of Biology and Applied Physics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1431-8533
Karl DeisserothDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0001-9440-3967
Attila LosonczyDepartment of Neuroscience, Columbia University, New York, NY, USA.
Ivan SolteszDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1493-3744

Funding

Towards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory ReplayU19NS104590 · NINDS · STANFORD UNIVERSITY · PI BUZSAKI, GYORGY, LISMAN, JOHN E · 2017 to 2021
$13.2M
Microcircuit, cellular and molecular dissection of impaired hippocampal function in a mouse model of the 22q11.2 deletionR01MH124047 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOGOS, JOSEPH A, LOSONCZY, ATTILA · 2020 to 2024
$3.8M
EPILEPSY TRAINING PROGRAMT32NS007280 · NINDS · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 1985 to 2020
$3.6M
Experimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representationsR01MH124867 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOSONCZY, ATTILA, POIRAZI, PANAYIOTA · 2021 to 2025
$3.4M
Discovery and characterization of brain-wide neuromodulatory circuits regulating arousalR00MH112840 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOVETT-BARRON, MATTHEW · 2020 to 2022
$746k
Discovery and characterization of brain-wide neuromodulatory circuits regulating arousalK99MH112840 · NIMH · STANFORD UNIVERSITY · PI LOVETT-BARRON, MATTHEW · 2017 to 2018
$242k
Perisomatic inhibition in epilepsyK99NS117795 · NINDS · STANFORD UNIVERSITY · PI DUDOK, BARNA · 2020 to 2021
$177k
NIMH NIH HHS K99 MH112840NIMH NIH HHS R00 MH112840NIMH NIH HHS R01 MH124047NIMH NIH HHS R01 MH124867NINDS NIH HHS K99 NS117795NINDS NIH HHS T32 NS007280NINDS NIH HHS U19 NS104590
6 · The paper itself

Abstract

Locomotor speed is a basic input used to calculate one’s position, but where this signal comes from is unclear. We identified neurons in the supramammillary nucleus (SuM) of the rodent hypothalamus that were highly correlated with future locomotor speed and reliably drove locomotion when activated. Robust locomotion control was specifically identified in

Indexed as

LocomotionAction PotentialsAnimalsHippocampusHypothalamus, PosteriorMiceMice, Inbred C57BLNeural PathwaysNeuronsRatsSpatial NavigationSubstance PTheta RhythmSubstance P

Identifiers

PMID34914519
PMCPMC9154354

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.