Evidence map›Paper›PMID 34914057›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Development of a Bacterial Nanoparticle Vaccine Against Escherichia coli.

Melibea Berzosa, Yadira Pastor, Carlos Gamazo, Juan Manuel Irache

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Melibea BerzosaDepartment of Microbiology and Parasitology, Institute of Tropical Health, University of Navarra, Pamplona, Spain.
Yadira PastorDepartment of Microbiology and Parasitology, Institute of Tropical Health, University of Navarra, Pamplona, Spain.
Carlos GamazoDepartment of Microbiology and Parasitology, Institute of Tropical Health, University of Navarra, Pamplona, Spain. cgamazo@unav.es.
Juan Manuel IracheDepartment of Technology and Pharmaceutical Chemistry, University of Navarra, Pamplona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, different subunit-based vaccine strategies against enterobacteria are being investigated. Among those, bacterial outer membrane vesicles (OMV) are promising candidates because of their immunogenic properties and safety. In order to develop an effective vaccine against this kind of pathogens, it is important to induce both systemic and mucosal immunity. For that reason, the oral route of administration would be an adequate option; although it still represents a challenge due to the particular and harsh conditions of the gut. To overcome these inconveniences, different strategies have been proposed, including the use of polymeric nanoparticles based on the copolymer between methyl vinyl ether and maleic anhydride (Gantrez AN). In the present work, a simple procedure for the preparation of heat-induced OMV (named as HT) obtained from Enterotoxigenic Escherichia coli (ETEC) loaded into these poly(anhydride) nanoparticles is described.

Indexed as

Escherichia coli InfectionsNanoparticlesAntibodies, BacterialAntigens, BacterialEnterotoxigenic Escherichia coliEscherichia coli ProteinsEscherichia coli VaccinesHumansAntibodies, BacterialAntigens, BacterialEscherichia coli ProteinsEscherichia coli VaccinesAcellular vaccinesEscherichia coliETECGantrez® ANNanoparticlesOuter membrane vesicles

Identifiers

PMID34914057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.