Evidence map›Paper›PMID 34914035›Full record

ReviewOphthalmology and therapy2022

The Eye of the Storm: COVID-19 Vaccination and the Eye.

Xin Le Ng, Bjorn Kaijun Betzler, Sean Ng, Soon Phaik Chee, Lakshminarayanan Rajamani, Amit Singhal, Andres Rousselot, Carlos E Pavesio, Vishali Gupta, Marc D de Smet and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Ophthalmology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Review of Ophthalmic Symptoms in COVID-19.Clinical ophthalmology (Auckland, N.Z.) · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Dacryoadenitis post COVID-19 infection and immunization.Indian journal of ophthalmology · 2023
    Article
  11. Covid-19 and its relation to the human eye: transmission, infection, and ocular manifestations.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Retinal Changes After COVID-19 Infection and COVID-19 Vaccination.International medical case reports journal · 2023
    Article
  18. Article
  19. COVID-19 vaccination and recurrent anterior uveitis.Indian journal of ophthalmology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 5 countries.

Xin Le NgNational Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, 308433, Singapore.
Bjorn Kaijun BetzlerYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Sean NgLee Kong Chian School of Medicine, Singapore, Singapore.
Soon Phaik CheeSingapore National Eye Centre, Singapore, Singapore.
Lakshminarayanan RajamaniSingapore Eye Research Institute, The Academia, Singapore, Singapore.
Amit SinghalA*STAR ID Labs & Singapore Immunology Network (SIgN), Singapore, Singapore.
Andres RousselotDepartment of Ophthalmology, Universidad del Salvador, Buenos Aires, Argentina.
Carlos E PavesioMoorfields Eye Hospital, NHS Foundation Trust, London, UK.
Vishali GuptaDepartment of Ophthalmology, Advance Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Marc D de SmetMicroInvasive Ocular Surgery Clinic, Lausanne, Switzerland.
Rupesh AgrawalNational Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, 308433, Singapore. rupesh_agrawal@ttsh.com.sg.ORCID http://orcid.org/0000-0002-6662-5850
Moorfields Eye Hospital NHS Foundation Trust · GBNational University of Singapore · SGAgency for Science, Technology and Research · SGLeiden University · NLPost Graduate Institute of Medical Education and Research · INSingapore Eye Research Institute · SGTan Tock Seng Hospital · SGUniversidad del Salvador · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has galvanized the global response towards the development of new vaccines based on novel technologies at an unprecedented pace. Since the widespread implementation of vaccination campaigns, case reports on vaccines' systemic side effects, including ocular manifestations, have emerged. Since administered vaccines are generally not able to cause the disease in the recipient, or induce an immune response against the pathogen, we hypothesize that the development of ocular phenomena post-COVID-19 vaccination may occur via an immune response elicited by the vaccine. Of many, the most common ocular adverse events include facial nerve palsy, central venous sinus thrombosis and acute anterior uveitis. These COVID-19 vaccine-induced ocular (CVIO) adverse events could resemble the ocular findings in some of the COVID-19 patients. This review will provide a comprehensive overview of published ocular side effects potentially associated with COVID-19 vaccination and serve as a springboard for further research into CVIO adverse events.

Indexed as

Adverse eventsCOVID-19Ocular manifestationSide effectsUveitisVaccinationVaccine

Identifiers

PMID34914035
PMCPMC8675299
OpenAlexW4200384928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.