ArticleNeurosurgical review2022
Stimulated Raman histology in the neurosurgical workflow of a major European neurosurgical center - part A.
Article in Neurosurgical review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Diagnostic performance and safety of stereotactic frame-based biopsy for sub centimeter intracranial lesions: A matched cohort analysis.Neurosurgical review · 2026Article
- Frozen agarose-assisted tissue preparation for stimulated Raman histology enables rapid intraoperative assessment of peripheral nerve integrity.Brain & spine · 2026Article
- The Freiburg framework for multimodalFrontiers in synaptic neuroscience · 2026Article
- Influence of preprocessing of stimulated Raman scattering images on the performance of deep neural networks for detecting cancer tissue.Quantitative imaging in medicine and surgery · 2025Article
- Three-photon microscopy: an emerging technique for deep intravital brain imaging.Nature reviews. Neuroscience · 2025Review
- A single-institution experience with intraoperativeFrontiers in oncology · 2025Article
- Intraoperative classification of CNS lymphoma and glioblastoma by AI-based analysis of Stimulated Raman Histology (SRH).Brain & spine · 2025Article
- Image Quality Assessment and Reliability Analysis of Artificial Intelligence-Based Tumor Classification of Stimulated Raman Histology of Tumor Biobank Samples.Diagnostics (Basel, Switzerland) · 2024Article
- Artificial Intelligence-Assisted Stimulated Raman Histology: New Frontiers in Vibrational Tissue Imaging.Cancers · 2024Review
- Current Applications of Raman Spectroscopy in Intraoperative Neurosurgery.Biomedicines · 2024Review
- Advancements in Neurosurgical Intraoperative Histology.Tomography (Ann Arbor, Mich.) · 2024Review
- [Intraoperative stimulated Raman histology for personalized brain tumor surgery].Chirurgie (Heidelberg, Germany) · 2024Review
- Clinical Validation of Stimulated Raman Histology for Rapid Intraoperative Diagnosis of Central Nervous System Tumors.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2023Article
- Stimulated Raman histology for histological evaluation of oral squamous cell carcinoma.Clinical oral investigations · 2023Article
- Technical report: surgical preparation of human brain tissue for clinical and basic research.Acta neurochirurgica · 2023Article
- Intraoperative microscopic autofluorescence detection and characterization in brain tumors using stimulated Raman histology and two-photon fluorescence.Frontiers in oncology · 2023Article
- Advances, technological innovations, and future prospects in stereotactic brain biopsies.Neurosurgical review · 2022Review
- Surgical Treatment of Glioblastoma: State-of-the-Art and Future Trends.Journal of clinical medicine · 2022Review
- From Research to Diagnostic Application of Raman Spectroscopy in Neurosciences: Past and Perspectives.Free neuropathology · 2022Article
- Artificial intelligence-based analysis and diagnosis of intradural extramedullary spinal tumors by stimulated Raman histology.Neuro-oncology advancesArticle
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Authors and funding
15 authors.
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Abstract
Histopathological diagnosis is the current standard for the classification of brain and spine tumors. Raman spectroscopy has been reported to allow fast and easy intraoperative tissue analysis. Here, we report data on the intraoperative implementation of a stimulated Raman histology (SRH) as an innovative strategy offering intraoperative near real-time histopathological analysis. A total of 429 SRH images from 108 patients were generated and analyzed by using a Raman imaging system (Invenio Imaging Inc.). We aimed at establishing a dedicated workflow for SRH serving as an intraoperative diagnostic, research, and quality control tool in the neurosurgical operating room (OR). First experiences with this novel imaging modality were reported and analyzed suggesting process optimization regarding tissue collection, preparation, and imaging. The Raman imaging system was rapidly integrated into the surgical workflow of a large neurosurgical center. Within a few minutes of connecting the device, the first high-quality images could be acquired in a "plug-and-play" manner. We did not encounter relevant obstacles and the learning curve was steep. However, certain prerequisites regarding quality and acquisition of tissue samples, data processing and interpretation, and high throughput adaptions must be considered. Intraoperative SRH can easily be integrated into the workflow of neurosurgical tumor resection. Considering few process optimizations that can be implemented rapidly, high-quality images can be obtained near real time. Hence, we propose SRH as a complementary tool for the diagnosis of tumor entity, analysis of tumor infiltration zones, online quality and safety control and as a research tool in the neurosurgical OR.
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