ArticleeLife2021
Parallel processing by distinct classes of principal neurons in the olfactory cortex.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Integrative analysis of single-cell multi-omics reveals heterogeneity in piriform cortex principal neurons and their selective vulnerability in Alzheimer's disease.Clinical and translational medicine · 2026Article
- Experience and behavior modulate piriform cortex odor representation in freely moving mice.iScience · 2026Article
- A topographical organization in the primary olfactory cortex.Nature communications · 2026Article
- Projection-specific Routing of Odor Information in the Olfactory Cortex.bioRxiv : the preprint server for biology · 2025Article
- Reinforced Odor Representations in the Anterior Olfactory Nucleus Can Serve as Memory Traces for Conspecifics.eNeuro · 2025Article
- Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal.Nature communications · 2025Article
- Lateral entorhinal cortex afferents reconfigure the activity in piriform cortex circuits.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Pyrfume: A window to the world's olfactory data.Scientific data · 2024Article
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex.Nature communications · 2024Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal reward contingency signals during rule-reversal.bioRxiv : the preprint server for biology · 2023Article
- Experience-dependent evolution of odor mixture representations in piriform cortex.PLoS biology · 2023Article
- Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex.eLife · 2023Article
- Electrophysiological Recordings from Identified Cell Types in the Olfactory Cortex of Awake Mice.Methods in molecular biology (Clifton, N.J.) · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Understanding how distinct neuron types in a neural circuit process and propagate information is essential for understanding what the circuit does and how it does it. The olfactory (piriform, PCx) cortex contains two main types of principal neurons, semilunar (SL) and superficial pyramidal (PYR) cells. SLs and PYRs have distinct morphologies, local connectivity, biophysical properties, and downstream projection targets. Odor processing in PCx is thought to occur in two sequential stages. First, SLs receive and integrate olfactory bulb input and then PYRs receive, transform, and transmit SL input. To test this model, we recorded from populations of optogenetically identified SLs and PYRs in awake, head-fixed mice. Notably, silencing SLs did not alter PYR odor responses, and SLs and PYRs exhibited differences in odor tuning properties and response discriminability that were consistent with their distinct embeddings within a sensory-associative cortex. Our results therefore suggest that SLs and PYRs form parallel channels for differentially processing odor information in and through PCx.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.