Evidence map›Paper›PMID 34913532›Full record

ArticleProtein science : a publication of the Protein Society2022

The molecular basis for the development of adult T-cell leukemia/lymphoma in patients with an IRF4

Srinivasan Sundararaj, Sandali Seneviratne, Simon J Williams, Anselm Enders, Marco G Casarotto

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Srinivasan SundararajJohn Curtin School of Medical Research, Australian National University, Canberra, Australia.ORCID 0000-0002-9112-2454
Sandali SeneviratneJohn Curtin School of Medical Research, Australian National University, Canberra, Australia.ORCID 0000-0001-5626-7968
Simon J WilliamsResearch School of Biology, Australian National University, Canberra, Australia.ORCID 0000-0003-4781-6261
Anselm EndersDepartment of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australia.ORCID 0000-0001-5933-6463
Marco G CasarottoJohn Curtin School of Medical Research, Australian National University, Canberra, Australia.ORCID 0000-0002-0571-7671
Australian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interferon regulatory factor 4 (IRF4) is an essential regulator in the development of many immune cells, including B- and T-cells and has been implicated directly in numerous hematological malignancies, including adult T-cell leukemia/lymphoma (ATLL). Recently, an activating mutation in the DNA-binding domain of IRF4 (IRF4

Indexed as

Interferon Regulatory FactorsLeukemia-Lymphoma, Adult T-CellAdultHumansInterferon Regulatory Factor-4MutationInterferon Regulatory Factor-4Interferon Regulatory Factorsadult T-cell leukemia/lymphomacrystal structureinterferon regulatory factor 4 (IRF4)protein-DNA complexprotein-DNA interactiontranscription factor

Identifiers

PMID34913532
PMCPMC8927869
OpenAlexW4200148419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.