Evidence map›Paper›PMID 34913020›Full record

ArticleJournal of the Endocrine Society2022

Ergocalciferol in New-onset Type 1 Diabetes: A Randomized Controlled Trial.

Benjamin Udoka Nwosu, Sadichchha Parajuli, Gabrielle Jasmin, Jody Fleshman, Rohit B Sharma, Laura C Alonso, Austin F Lee, Bruce A Barton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Vitamin D and Beta Cells in Type 1 Diabetes: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  5. Trial
  6. Type 1 Diabetes Mellitus Pathogenesis: Mechanisms, Early Diagnostic Strategies, and Emerging Therapeutic Approaches.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  7. Article
  8. Prolonging Partial Remission in Type 1 Diabetes: The Role of Low-Carbohydrate Diet: A Literature Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  9. Article
  10. Article
  11. Vitamin DFrontiers in immunology · 2026
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Type 1 Diabetes Mellitus and Vitamin D.International journal of molecular sciences · 2025
    Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Benjamin Udoka NwosuDivision of Pediatric Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.ORCID https://orcid.org/0000-0003-2212-0276
Sadichchha ParajuliDivision of Pediatric Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Gabrielle JasminDivision of Pediatric Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Jody FleshmanDivision of Pediatric Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Rohit B SharmaDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Laura C AlonsoDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0001-5056-8970
Austin F LeeDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Bruce A BartonDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.ORCID https://orcid.org/0000-0001-7878-8895
University of Massachusetts Chan Medical School · USCornell University · US

Funding

Vitamin D and Residual Beta-Cell Function in Type 1 DiabetesR21DK113353 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI NWOSU, BENJAMIN UDOKA · 2017 to 2019
$628k
NIDDK NIH HHS R21 DK113353
6 · The paper itself

Abstract

contextThe effect of the anti-inflammatory and immunomodulatory actions of vitamin D on the duration of partial clinical remission (PR) in youth with type 1 diabetes (T1D) is unclear.

objectiveThis work aimed to determine the effect of adjunctive ergocalciferol on residual β-cell function (RBCF) and PR in youth with newly diagnosed T1D who were maintained on a standardized insulin treatment protocol. The hypothesis was that ergocalciferol supplementation increases RBCF and prolongs PR.

methodsA 12-month, randomized, double-blind, placebo-controlled trial was conducted of 50 000 IU of ergocalciferol per week for 2 months, and then once every 2 weeks for 10 months, vs placebo in 36 individuals aged 10 to 21 years, with T1D of less than 3 months and a stimulated C-peptide (SCP) level greater than or equal to 0.2 nmol/L (≥ 0.6 ng/mL). The ergocalciferol group had 18 randomly assigned participants (10 male/8 female), mean age 13.3 ± 2.8 years, while the control group had 18 participants (14 male/4 female), aged 14.3 ± 2.9 years.

resultsThe ergocalciferol treatment group had statistically significantly higher serum 25-hydroxyvitamin D at 6 months (

conclusionErgocalciferol statistically significantly reduced serum TNF-α concentration and the rates of increase both in A

Indexed as

C-peptideergocalciferolpartial clinical remissionpediatricstype 1 diabetes

Identifiers

PMID34913020
PMCPMC8668202
OpenAlexW3216517410

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.