Evidence map›Paper›PMID 34912899›Full record

Observational studyJournal of immunology research2021

Transcriptome Analysis of Large to Giant Congenital Melanocytic Nevus Reveals Cell Cycle Arrest and Immune Evasion: Identifying Potential Targets for Treatment.

Boxuan Wei, Jieyu Gu, Ran Duan, Bowen Gao, Min Wu, Shengliang Zhou, Xiaolu Huang, Feng Xie

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Boxuan WeiDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Medical College of Shanghai Jiaotong University, Shanghai, China.ORCID https://orcid.org/0000-0003-2363-2759
Jieyu GuDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Medical College of Shanghai Jiaotong University, Shanghai, China.ORCID https://orcid.org/0000-0001-8794-9208
Ran DuanDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Medical College of Shanghai Jiaotong University, Shanghai, China.ORCID https://orcid.org/0000-0001-9429-0501
Bowen GaoDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Medical College of Shanghai Jiaotong University, Shanghai, China.ORCID https://orcid.org/0000-0003-4009-2299
Min WuDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Medical College of Shanghai Jiaotong University, Shanghai, China.ORCID https://orcid.org/0000-0001-5462-6920
Shengliang ZhouDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Medical College of Shanghai Jiaotong University, Shanghai, China.ORCID https://orcid.org/0000-0002-8152-0344
Xiaolu HuangDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Medical College of Shanghai Jiaotong University, Shanghai, China.ORCID https://orcid.org/0000-0001-6874-3538
Feng XieDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Medical College of Shanghai Jiaotong University, Shanghai, China.ORCID https://orcid.org/0000-0003-3322-7271
Shanghai Ninth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large to giant congenital melanocytic nevus (lgCMN) is a benign cutaneous tumor that develops during embryogenesis. A large number of lgCMN patients are ineligible for surgical treatment; hence, there is an urgent need to develop pharmacological treatments. Clinically, tumorigenesis and progression essentially halt after birth, resulting in the homeostasis of growth arrest and survival. Numerous studies have employed whole-genome or whole-exome sequencing to clarify the etiology of lgCMN; however, transcriptome sequencing of lgCMN is still lacking. Through comprehensive transcriptome analysis, this study elucidated the ongoing regulation and homeostasis of lgCMN and identified potential targets for treatment. Transcriptome sequencing, identification of differentially expressed genes and hub genes, protein-protein network construction, functional enrichment, pathway analysis, and gene annotations were performed in this study. Immunohistochemistry, real-time quantitative PCR, immunocytofluorescence, and cell cycle assays were employed for further validation. The results revealed several intriguing phenomena in lgCMN, including

Indexed as

AdolescentAntineoplastic AgentsBiomarkers, TumorCarcinogenesisCell Cycle CheckpointsChildChild, PreschoolFemaleGene Expression ProfilingHumansImmunohistochemistryImmunotherapyInfantMaleMelanocytesMolecular Targeted TherapyAntineoplastic AgentsBiomarkers, Tumor

Identifiers

PMID34912899
PMCPMC8668353
OpenAlexW4200558478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.