ArticleERJ open research2021
Breastfeeding and risk of childhood asthma: a systematic review and meta-analysis.
Article in ERJ open research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- The association between Helicobacter pylori infection and asthma risk: an updated systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Associations of breastfeeding with maternal and child health outcomes: umbrella review.The American journal of clinical nutrition · 2025Pooled it
- Non-exclusive breastfeeding is associated with pneumonia and asthma in under-five children: an umbrella review of systematic review and meta-analysis.International breastfeeding journal · 2025Pooled it
- Prevalence of asthma among children and adolescents in WHO's Eastern Mediterranean Region: a meta-analysis of over 0.5 million participants.BMC public health · 2024Pooled it
- Examining Relationships Between Multiple Adverse Social Determinants of Health, Maternal Depressive Symptoms, Timing of Solid Food Introduction, and Breastfeeding Duration Among Black or African American Women.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2026Article
- Article
- Urgent investment needed to reclaim lactation care and training to support Indigenous women, babies, families, and communities.Health promotion international · 2026Article
- Asthma management in pregnancy and lactation: A review of current evidence and best practice recommendations.NPJ primary care respiratory medicine · 2026Review
- Breastfeeding Duration and Airway Inflammation in Children With Asthma Living in a Polluted Megacity.The clinical respiratory journal · 2026Observational
- Single-cell transcriptomics of leukocyte-enriched human milk reveals a highly diverse and adapted myeloid compartment.PloS one · 2026Article
- The role of the early-life gut microbiome in childhood asthma.Gut microbes · 2025Review
- Assembly of the infant gut microbiome and resistome are linked to bacterial strains in mother's milk.Nature communications · 2025Article
- The protective effect of breastfeeding on infant inflammation: a mediation analysis of the plasma lipidome and metabolome.BMC medicine · 2025Article
- Article
- 2024 edition of the Rourke Baby Record.Canadian family physician Medecin de famille canadien · 2025Review
- Why Every Asthma Patient Tells a Different Story.Journal of clinical medicine · 2025Article
- Microbiological Foundations to Optimise Intrinsic Capacity and Promote Healthy Ageing: An Integration Into the Life Course Approach.Aging cell · 2025Review
- Network analysis reveals protein modules associated with childhood respiratory diseases.The Journal of allergy and clinical immunology · 2025Article
- Prenatal Maternal Stress and Pediatric Asthma Across Development: Adolescent Female-Specific Vulnerability.Child psychiatry and human development · 2025Article
- Moderate-to-late prematurity: understanding respiratory consequences and modifiable risk factors.European respiratory review : an official journal of the European Respiratory Society · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relationship between breastfeeding and the development of paediatric asthma.
methodsA systematic review and meta-analysis was conducted with MEDLINE, Embase, CINAHL and ProQuest Nursing and Allied Health source databases. Retrospective/prospective cohorts in children aged <18 years with breastfeeding exposure reported were included. The primary outcome was a diagnosis of asthma by a physician or using a guideline-based criterion. A secondary outcome was asthma severity.
results42 studies met inclusion criteria. 37 studies reported the primary outcome of physician-/guideline-diagnosed asthma, and five studies reported effects on asthma severity. Children with longer duration/more breastfeeding compared to shorter duration/less breastfeeding have a lower risk of asthma (OR 0.84, 95% CI 0.75-0.93; I
conclusionThe findings suggest that the duration and exclusivity of breastfeeding are associated with a lower risk of asthma in children aged <7 years.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.