Evidence map›Paper›PMID 34912844›Full record

ArticleFrontiers in molecular biosciences2021

CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma.

Xue Kong, Ruiting Xu, Wei Wang, Minghui Zeng, Yuan Li, Mengyu Lin, Wenchao Zhou, Xianming Fu, Haibo Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xue KongSchool of Medicine, Shandong University, Jinan, China.
Ruiting XuDivision of Life Sciences and Medicine, The First Affiliated Hospital of USTC, Intelligent Pathology Institute, University of Science and Technology of China, Hefei, China.
Wei WangDepartment of Pathology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
Minghui ZengDepartment of Neurosurgery, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
Yuan LiDivision of Life Sciences and Medicine, The First Affiliated Hospital of USTC, Intelligent Pathology Institute, University of Science and Technology of China, Hefei, China.
Mengyu LinDivision of Life Sciences and Medicine, The First Affiliated Hospital of USTC, Intelligent Pathology Institute, University of Science and Technology of China, Hefei, China.
Wenchao ZhouDivision of Life Sciences and Medicine, The First Affiliated Hospital of USTC, Intelligent Pathology Institute, University of Science and Technology of China, Hefei, China.
Xianming FuSchool of Medicine, Shandong University, Jinan, China.
Haibo WuDepartment of Pathology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are usually enriched in neural tissues, yet about 80% circRNAs have lower expression in gliomas relative to normal brains, highlighting the importance of circRNAs as tumor suppressors. However, the clinical impact as well as the pathways regulated by the tumor-suppressive circRNAs remain largely unknown in glioblastoma (GBM). Through bioinformatic analysis followed by experimental validation, we found that hsa_circ_0114014 (circLRRC7) was dramatically down-regulated in GBM when compared with normal brain tissues (

Indexed as

circRNAGBMhsa_circ-0114014miR-1281miRNAPDXPtumor suppressor

Identifiers

PMID34912844
PMCPMC8667166

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.