Evidence map›Paper›PMID 34912755›Full record

ArticleFrontiers in pediatrics2021

Mechanisms of Congenital Myasthenia Caused by Three Mutations in the

Xiaona Luo, Chunmei Wang, Longlong Lin, Fang Yuan, Simei Wang, Yilin Wang, Anqi Wang, Chao Wang, Shengnan Wu, Xiaoping Lan and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  3. The Role ofmedRxiv : the preprint server for health sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Xiaona LuoDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Chunmei WangDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Longlong LinDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Fang YuanDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Simei WangDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Yilin WangDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Anqi WangDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Chao WangDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Shengnan WuDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Xiaoping LanDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Quanmei XuDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Rongrong YinDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Hongyi ChengDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Yuanfeng ZhangDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Jiaming XiDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Jie ZhangDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Xiaomin SunDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Jingbin YanNational Health Commission (NHC) Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology and Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.
Fanyi ZengNational Health Commission (NHC) Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology and Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.
Yucai ChenDepartment of Neurology, Shanghai Children's Hospital, Shanghai JiaoTong University, Shanghai, China.
Shanghai Jiao Tong University · CNShanghai Children's Hospital · CNNational Health and Family Planning Commission · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gene encoding collagen like tail subunit of asymmetric acetylcholinesterase (COLQ) is responsible for the transcription of three strands of collagen of acetylcholinesterase, which is attached to the endplate of neuromuscular junctions. Mutations in the

Indexed as

CMSCOLQ geneexon deletionmissense mutationsplicing mutation

Identifiers

PMID34912755
PMCPMC8667818
OpenAlexW3217615022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.