ReviewFrontiers in oncology2021
Adaptive Radiation Therapy in the Treatment of Lung Cancer: An Overview of the Current State of the Field.
Review in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 39 citations in OpenAlex.
- Clinical implementation of automated IMRT/VMAT planning for lung cancer radiation therapy using the expedited constrained hierarchical optimization (ECHO) system.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2026Article
- One-for-All Adaptive Radiotherapy Planning Agent: A Foundation Framework for Daily CBCT-guided Radiotherapy.ArXiv · 2026Article
- Advances in mucosal injury mechanisms in radiation-induced esophagitis associated with thoracic radiotherapy.Precision radiation oncology · 2026Review
- Auto-segmentation and dose accuracy evaluation of synthetic computed tomography generated from pelvis cone-beam computed tomography images using a cycle-generative adversarial network with a novel loss function.Physics and imaging in radiation oncology · 2026Article
- Monitoring lung tumour volume on daily cone beam CT; is it achievable in a real-world setting?Technical innovations & patient support in radiation oncology · 2025Article
- Cumulative Dose Analysis in Adaptive Carbon Ion Radiotherapy for Locally Advanced Non-Small Cell Lung Cancer.Cancers · 2025Article
- Improving efficiency in lung SAbR planning using integrated tools for X-ray based adaptive radiotherapy.Journal of applied clinical medical physics · 2025Article
- Time series analysis of dosimetric changes in target volumes and organs at risk monitored by cone beam computed tomography during radiotherapy for non-small-cell lung cancer.Physics and imaging in radiation oncology · 2025Article
- New Approaches in Radiotherapy.Cancers · 2025Review
- Assessing Dosimetric Benefits of Cone Beam Computed Tomography-Guided Online Adaptive Radiation Treatment Frequencies for Lung Cancer.Advances in radiation oncology · 2025Article
- Adaptive treatment margins to reduce organs at risk dose in patients with no or minimal anatomical changes in radiotherapy of non-small cell lung cancer.Physics and imaging in radiation oncology · 2025Article
- Updates in Management of Unresectable Stage III Non Small Cell Lung Cancer: A Radiation Oncology Perspective.Cancers · 2024Review
- Circulating tumor DNA kinetics: A future tool for radiation therapy personalization in lung cancer?The journal of liquid biopsy · 2024Article
- New perspectives on inoperable early-stage lung cancer management: Clinicians, physicists, and biologists unveil strategies and insights.The journal of liquid biopsy · 2024Review
- Article
- Advances in Non-Small Cell Lung Cancer: Current Insights and Future Directions.Journal of clinical medicine · 2024Review
- Factors that Influence the Need to Start Adaptive Radiotherapy.Journal of immunotherapy and precision oncology · 2024Article
- Adaptive Lung Radiation Therapy in the Era of Immunotherapy: A Single-Center Retrospective Study.Advances in radiation oncology · 2024Article
- Evaluating the Necessity of Adaptive RT and the Role of Deformable Image Registration in Lung Cancer with Different Pathologic Classifications.Diagnostics (Basel, Switzerland) · 2023Article
- ScatterNet for projection-based 4D cone-beam computed tomography intensity correction of lung cancer patients.Physics and imaging in radiation oncology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Lung cancer treatment is constantly evolving due to technological advances in the delivery of radiation therapy. Adaptive radiation therapy (ART) allows for modification of a treatment plan with the goal of improving the dose distribution to the patient due to anatomic or physiologic deviations from the initial simulation. The implementation of ART for lung cancer is widely varied with limited consensus on who to adapt, when to adapt, how to adapt, and what the actual benefits of adaptation are. ART for lung cancer presents significant challenges due to the nature of the moving target, tumor shrinkage, and complex dose accumulation because of plan adaptation. This article presents an overview of the current state of the field in ART for lung cancer, specifically, probing topics of: patient selection for the greatest benefit from adaptation, models which predict who and when to adapt plans, best timing for plan adaptation, optimized workflows for implementing ART including alternatives to re-simulation, the best radiation techniques for ART including magnetic resonance guided treatment, algorithms and quality assurance, and challenges and techniques for dose reconstruction. To date, the clinical workflow burden of ART is one of the major reasons limiting its widespread acceptance. However, the growing body of evidence demonstrates overwhelming support for reduced toxicity while improving tumor dose coverage by adapting plans mid-treatment, but this is offset by the limited knowledge about tumor control. Progress made in predictive modeling of on-treatment tumor shrinkage and toxicity, optimizing the timing of adaptation of the plan during the course of treatment, creating optimal workflows to minimize staffing burden, and utilizing deformable image registration represent ways the field is moving toward a more uniform implementation of ART.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.