Evidence map›Paper›PMID 34912575›Full record

ArticleJournal of ophthalmology2021

Comparison between Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor Levels in Rhegmatogenous Retinal Detachment.

Andi Muhammad Ichsan, Dyah Ayu Windy, Habibah Setyawati Muhiddin, Budu, Muhammad Nasrum Massi, Itzar Chaidir Islam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Andi Muhammad IchsanDepartment of Ophthalmology, Medical Faculty, Hasanuddin University, Makassar, Indonesia.ORCID https://orcid.org/0000-0002-8844-2211
Dyah Ayu WindyDepartment of Ophthalmology, Medical Faculty, Hasanuddin University, Makassar, Indonesia.
Habibah Setyawati MuhiddinDepartment of Ophthalmology, Medical Faculty, Hasanuddin University, Makassar, Indonesia.ORCID https://orcid.org/0000-0003-3019-2691
BuduDepartment of Ophthalmology, Medical Faculty, Hasanuddin University, Makassar, Indonesia.ORCID https://orcid.org/0000-0003-3742-079X
Muhammad Nasrum MassiDepartment of Microbiology, Medical Faculty, Hasanuddin University, Makassar, Indonesia.
Itzar Chaidir IslamDepartment of Ophthalmology, Medical Faculty, Hasanuddin University, Makassar, Indonesia.ORCID https://orcid.org/0000-0002-5327-4553
Hasanuddin University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to assess vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) levels within vitreous and blood serum samples of patients with rhegmatogenous retinal detachment (RRD) and their relationship to the development of proliferative vitreoretinopathy (PVR).

methodsSeventeen eyes of patients with RRD were included in the RRD group and divided into three subgroups: RRD without PVR, RRD with PVR grades A and B, and RRD with PVR grade C. Five control eyes (nucleus and intraocular lens drop) were included in this study. Blood serum and vitreous samples were collected during vitrectomy. VEGF-A and PDGF-AA levels were determined by enzyme-linked immunosorbent assay.

resultsThe mean vitreous VEGF-A level in the RRD group was 131.71 ± 58.25 pg/mL, and the mean vitreous PDGF-AA level was 174.62 ± 65.17 pg/mL. Both levels were significantly higher in the RRD group compared with the control group (

conclusionBased on the tendency of VEGF-A and PDGF-AA levels, RRD surgery has to be performed as soon as possible prior to retinal cell death and membrane proliferative formation.

Identifiers

PMID34912575
PMCPMC8668303
OpenAlexW4200010050

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.