ArticleInternational journal of preventive medicine2021
Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
Article in International journal of preventive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06445933 (The Correlation Between Vitamin B6 and Avoiding Depression in Pregnant and Peri-partum Women), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Correlation Between Vitamin B6 and Avoiding Depression in Pregnant and Peri-partum Women
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Proactive approaches to preventing postpartum depression in non-depressive pregnant women: a comprehensive scoping review.Frontiers in global women's health · 2025Pooled it
- Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial.BMC musculoskeletal disorders · 2022Trial
- Biomarkers of Postpartum Depression: A Narrative Review.Journal of clinical medicine · 2023Review
- Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders.Nutrients · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA low level of vitamin B6 may theoretically cause symptoms of depression.
aimsTo investigate the effect of vitamin B6 on the prevention of postpartum depression (PPD) among mothers at risk for PPD.
methodsThis single-blind, placebo-controlled clinical trial was conducted on 81 pregnant women who were at risk of PPD from February to July 2016 at six selected health centers in Isfahan, Iran. A simple random sampling method was adopted. Forty cases and 41 controls received 80 mg vitamin B6 and placebo, respectively from the 28
resultsForty-three subjects were assigned to each group and the final analysis comprised 81 subjects (40 in the case and 41 in the control groups), the mean age of the case and control groups being 5.8 ± 29.6 and 4.6 ± 28.2, respectively. The mean depression score was 10.4 ± 1.4 in the case and 9.3 ± 4.2 in control groups (
conclusionsVitamin B6 has a positive effect on reducing postpartum depression scores among mothers at risk for PPD. These may be clinically useful for preventing PPD in high-risk women.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.