Evidence map›Paper›PMID 34912500›Full record

ArticleJournal of oral microbiology2022

Quantification of torque teno virus (TTV) DNA in saliva and plasma samples in patients at short time before and after kidney transplantation.

Alexandre Mendes Batista, Matheus W Caetano, Maria A Stincarelli, Ana C Mamana, Rodrigo Melim Zerbinati, Dmitry J S Sarmento, Marina Gallottini, Rafael A V Caixeta, José Medina-Pestana, Bengt Hasséus and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of oral microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Torque teno virus in the lower respiratory tract: association with immunosuppression but not mortality in severe pneumonia-a multicenter retrospective cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Alexandre Mendes BatistaLaboratory of Virology, Institute of Tropical Medicine of São Paulo, University of São Paulo School of Medicine, São Paulo, Brazil.
Matheus W CaetanoLaboratory of Virology, Institute of Tropical Medicine of São Paulo, University of São Paulo School of Medicine, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-4135-4051
Maria A StincarelliDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-1046-4565
Ana C MamanaLaboratory of Virology, Institute of Tropical Medicine of São Paulo, University of São Paulo School of Medicine, São Paulo, Brazil.
Rodrigo Melim ZerbinatiLaboratory of Virology, Institute of Tropical Medicine of São Paulo, University of São Paulo School of Medicine, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-9936-9139
Dmitry J S SarmentoDepartment of Stomatology, University of São Paulo School of Dentistry, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7972-9141
Marina GallottiniDepartment of Stomatology, University of São Paulo School of Dentistry, São Paulo, Brazil.
Rafael A V CaixetaDepartment of Stomatology, University of São Paulo School of Dentistry, São Paulo, Brazil.
José Medina-PestanaDivision of Renal Transplantation, Kidney and Hypertension Hospital, Federal University of São Paulo School of Medicine, São Paulo, Brazil.
Bengt HasséusDepartment of Oral Medicine and Pathology, University of Gothenburg Institute of Odontology, Gothenburg, Sweden.ORCID https://orcid.org/0000-0003-3088-1550
Louise ZanellaLaboratory of Integrative Biology (LIBi), Scientific and Technological Bioresource Nucleus - Center for Excellence in Translational Medicine (BIOREN - CEMT), Universidad de La Frontera, Temuco, Chile.
Tania R Tozetto-MendozaLaboratory of Virology, Institute of Tropical Medicine of São Paulo, University of São Paulo School of Medicine, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-5659-1052
Simone GiannecchiniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Paulo H Braz-SilvaLaboratory of Virology, Institute of Tropical Medicine of São Paulo, University of São Paulo School of Medicine, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1842-9521
Universidade de São Paulo · BRUniversity of Florence · ITUniversidad de La Frontera · CLUniversidade Estadual da Paraíba · BRUniversidade Federal de São Paulo · BRUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral reports have proposed that the viral load of torque teno virus (TTV) in plasma is a biomarker of immune function in solid organ transplantation (SOT) and in allogeneic hematopoietic stem cell transplantation. Additionally, for the latter one, TTV-DNA quantification in saliva has also been suggested.

aimto investigate the correlation between the TTV viral load and immune function in paired saliva and plasma samples in patients on kidney transplantation. MATERIALS AND

methodsTTV-DNA viral load was quantified in paired samples of saliva and plasma from 71 patients before and a short-time after renal-transplantation by real-time PCR.

resultsThe data obtained from 213 paired samples showed a slight consistency in the comparison between saliva and plasma, with prevalence of TTV-DNA being 58%, 52% and 60% in saliva samples and 60%, 73% and 90% in plasma samples before and at 15-20 and 45-60 days after transplantation, respectively. Additionally, a high TTV viral load was observed in plasma at 15-20 and 45-60 days after transplantation compared to that observed in saliva at the same time.

conclusionsOverall, monitoring TTV-DNA in saliva samples could be an additional fast non-invasive option to assess the immune functionality in SOT populations.

Indexed as

immunosuppressionSalivasolid organ transplantationtorque teno virus

Identifiers

PMID34912500
PMCPMC8667915
OpenAlexW4200098947

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.